Tumeric worsens vitiligo
Dr. Weeks’ Comment: Whereas I frequently recommend curry/ turmeric/ curcumin to patients for its wonderful anti-oxidation benefits, here we see that, like all natural substances, it is a double edged sword and, accordingly, must be wielded carefully. Asians (whose culture appreciates this herb) have a worse risk of dermatological “splotching” (vitiligo) when they eat this herb, since it inhibits repigmentation of the skin.
Turmeric (Curcumin) – a widely used curry ingredient – can contribute to oxidative stress in Asian patients with acute Vitiligo
KU Schallreuter and H Rokos
Indian J Dermatol Venereol Leprol 72:57-59 (2006)
Our in vivo results show that curcumin can contribute to the oxidative stress in acute vitiligo and prevent repigmentation. Therefore, dermatologists and other doctors treating patients with this disease should be aware of this possible problem.
Vitiligo is an acquired skin disorder with the loss of native skin pigment, which affects about 0.5-1% of the world population. Increased H2O2 levels in the epidermis and in blood are one of many hallmarks of this disease. Elevated epidermal H2O2 levels in the mM range inactivate epidermal and systemic catalase. Restoration of the skin colour can be achieved after reduction of epidermal H2O2 levels using a topical applied pseudocatalase cream (PC-KUS). Recently it has been shown, that epidermal catalase as well as other affected enzymes recover after treatment with this modality.
However, to our surprise part of our Asian patient population showed only moderate improvement or no response at all. Since the Asian cuisine uses a big variety of spices in the daily nutrition, we asked the question whether turmeric (haldi), which is widely used in curries, could possibly contribute to the poor outcome of this treatment. Besides serving as spice, turmeric was and still is widely used for wound healing and skin lightening in Asia. Its major active yellow pigment is curcumin (diferuloyl methane). There is substantial literature on curcumin, describing anti-oxidant, anti-inflammatory as well as anti-carcinogenic properties. However, high concentrations can lead to reactive oxygen species (ROS) generation via semiquinone radicals.
Response rate in facial repigmentation after topical application of low-dose UVB-activated pseudocatalase (PC-KUS) twice per day after
(Photos were taken under WOOD’s light)
Based on the in vivo results, we evaluated 15 Asian patients with acute vitiligo, who consumed turmeric daily, and their response rate in facial repigmentation after topical application of low-dose UVB-activated pseudocatalase (PC-KUS) twice per day. After 6 months, none of them showed any significant repigmentation.
Therefore, we advised 8 patients to avoid this spice ingredient in their diet and continue the application of PC-KUS twice daily. There was a significant improvement of the response already after 2 months in these patients. After 6 months treatment, the facial repigmentation was nearly completed in 6 of the 8 patients, whereas only minor to moderate or no response was obtained in the 7 patients who continued using turmeric together with PC-KUS.
Posted by Brad Weeks, MD on October 2, 2009