Comparative Study Using Dermabrasion
Principle Investigator: Iltefat Hamzavi, MD
Study Location:
Henry Ford Department of Dermatology,
3031 West Grand Boulevard Detroit, MI 48202
The melanocyte keratinocyte transplant procedure (MKTP) involves transplantation of the skin cells that produce pigment from your normal skin to the depigmented skin. The procedure takes approximately 4 hours and is done under local anesthesia.
This is a prospective, open-label, parallel study comparing two different techniques for preparing the depigmented skin (carbon dioxide laser versus dermabrasion) and comparing two different wound dressings (collagen dressing versus vaseline impregnated gauze) for the melanocyte keratinocyte transplant procedure.
Eligibility Requirements:
- Must be 18 years of age or older
- Must have depigmented patches of skin
Exclusion Criteria:
- History of acral vitiligo (vitiligo on the hands or feet)
- Unstable vitiligo, defined as any new or enlarging areas of
depigmentation within the last 6 months) - History of thickened scars or keloids
- History of koebnerization (getting new areas of
depigmentation at sites of trauma, such as a cut, scrape, or burn)
The vitiligo patch will be divided into four quadrants. Each quadrant will be treated with the melanocyte keratinocyte transplant procedure, as follows:
- CO2 laser for denuding the epithelium Collagen dressing
- CO2 laser for denuding the epithelium Vaseline impregnated gauze dressing
- Dermabrasion for denuding the epithelium Collagen Dressing
- Dermabrasion for denuding the epithelium Vaseline impregnated gauze dressing
The patient will return to the clinic for the dressing removal 1 week post-procedure. Repigmentation of the treated areas will be assessed by in-person, or remote examination (emailed photographs) at monthly intervals (1-6 months) after MKTP.
To participate, or for more information, Contact: Dr. James L. Griffith
Phone: 313-916-6964 or Email: jgriff10@hfhs.org
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