Hi Lisa, LOL@ “I’m trying to wish them away. …
Comment posted on Black Pepper May Help Vitiligo by Nathalie Pelletier
Hi Lisa,
LOL@ “I’m trying to wish them away. : )” … good one! Im pretty sure that my white spots are vitiligo, but i might just try the selsun blue thing to be sure.
This site http://vitiligo.50webs.com/ is where i found some ideas for dietary changes that helped a little girl repigment. i havent tried changing my diet, but i’ve had a few people write to tell me that it worked for them when combined with sunning and taking supplements.
i’m off to read the story you left earlier…i look forward to hearing from you again.
all the very best
nathalie
Nathalie Pelletier also commented
- Dear H,
There is no permanent solution for vitiligo at this time. You can choose some keywords from the tag cloud (right column of this page) to read about different methods available to try to regain repigmentation. Many readers report regularly with results from their own experiments. These may offer something to help your daughter as well.
all the best to your daughter and you. - hi rich,
thanks for the update. it’s so exciting to see new freckling, isn’t it?
- Sharon, it is my great pleasure!
All the very best to you,
Nathalie - hi sharon,
try not to feel depressed. we are all here for you! why don’t you join our support group? it’s a wonderful community of people with vitiligo- you can communicate via email and we recently added a chat area.
i send you a hug
nathalie - hi jason,
your comments (which includes the wording u sent via email) can be found on the front page of vitiligocover.com in the headline section at the top of the page.thanks for all of your diligent record keeping…it’s going to help a lot of people
all the best
nathalie
Recent comments by Nathalie Pelletier
- The drug development process – Part 3 of 3
thank you, mary. I’m glad that you enjoyed the posts…and i have even more info to share with everyone. if you haven’t already, sign up for the rss feed and each new post will come directly to your email. - Vitiligo Cures From Around The World
Hi SV,
I know just how you feel. If I don’t put on my cover lotion, my vitiligo shows and, sadly, it stops me from doing even the simplest thing as going to the gym. School is much more important, though, and I urge you to talk to your professors. Explain your situation and how vitiligo makes you self-conscious. You may be very surprised at the help you will receive when they understand that your missing classes due to being lazy or uncaring. Dare to reach out for help, or at least their understanding
Nathalie - Vitiligo repigmentation success
man, you guys are making me work this morning, lol. i have re-posted the photos so that you are now able to click on them for an enlarged image. it is a bit difficult to discern the new pigmentation, but as someone who has experienced repigmentation, i can see that the after photo is correct. it is the subtle darkening around the edges that is the tell sign.
- First vitiligo world congress 2010
hi z,
never worry about long comments; that’s why i created this site. it’s a place that you can come and vent your frustrations, share your fears, and be there for others feeling the same as you.you on spot on about physician reaction to vitiligo patients, they should show compassion; afterall, if someone had severe burn scars and told their doctor that they feel chastised because they look different than the norm, the doctor would talk his patient through his pain or at the very least, recommend a therapist to help— he wouldn’t just scoff at the patient’s concerns.
until doctors improve their ‘bed side manner’ with vitiligo patients, perhaps it is up to us to bring it to their attention as it happens. next time you go in and share your feelings with him/her, if you feel dismissed, tell them. explain in a calm voice that even though vitiligo in and of itself has no physical symptoms other than discoloration, it is an emotionally debilitating disease and you would like more guidance on how to deal with this aspect.
big hugs,
nathalie - UV-protective drug to be tested for vitiligo
hi zz, at this early stage, there are no definitive answers to your (post fda approval) questions. i am sure the company must have a complete business plan concerning the distribution of scenesse, but until they get approval, chances are slim that they can share future plans. rest assured, as soon as there are answers, i will post them here.
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I’ve read about that and had ask a friend that lives in London to call and inquirer about it and the university said that the next trial will be in Oregon using the black pepper extract which is mixed into a compound and put on the skin topically. They also said that due to research and using human trials that it will take about 10 years before its used as a medication for vitiligo.
10 years?! Blast! Is there any way we could try using this ourselves? Is there some place to buy piperine compounds?
I have just started showing vitiligo.Is there no early treatment for permanent cure?
Have vitiligo for over 50 years—tried different products with no results. Please if you find a treatment let me know
Have vitiligo for over 50 years—tried different products with no results. Please if you find a treatment let me know
The worst thing about having vitiligo is that everyone can see it,in GODS name can someone find a cure!
I have vitiligo 3 years running, and am hoping that someone can find a cure. Until then I am going to try some things on this website hoping and praying that they will help.
Do you know where in Oregon the next trial will be?
Hi, i just wanted to say that i have a cousin that was diagnosed with vitiligo when he was 3 years old, the doctor found a small spot on his belly since that day they have treated him in cuba for around 9 years the spot disapear and he has no traces of vitiligo, in that country they have a good treatment, so if you can find info about that for you all it will be good, hope you all get better!!!!!
Somebody said above, he just started having vitiligo..my best suggestion would be to start taking neem tablets so that further spread would be arrested…I have Vitiligo for four years..when it started it sperad crazy and stopped spreading when I started taking neem tablets ..you can get neem tablets from many websites cheap…If you are in USA, you are screwed..they just give you Elidel and protopic for external application, which does not work all that great..Now I am trying to get some pigmentation for the depigmented areas…Tried pretty much everthing on the web without much help..The best thing was Narrow band UVB..But I don’t have a local clinic to go to after my job change…Bought a home UVB lamp which provided some help…
Pepper sounds great..I am planning to use ground black pepper and apply it from today onwards with water..what to do..till they make it commercially viable..best of luck
I had vitiligo and was treated with PRESCRIPTION SELSUN shampoo. You need a doctor to write a script for it. It does work. You cover your entire body with it and let it dry, then go to bed (in clothes you really don’t care about ruining) and in the morning wash it off. My spots were gone in less than a week and haven’t come back since. However, some people need to use it more then once, ask your dematologist about it.
Hi Roberta,
Thanks for your comment. I scoured the internet for info regarding the use of prescription selsun blue shampoo to cure vitiligo. what i found was that it is a good remedy for curing fungal infections which may often be misdiagnosed as vitiligo.
hmmm, i may try this just in case.
I left a comment under “Around the World” but then I found this too. I have to say, I’m wild about this site. I’m finding all kinds of interesting stuff out. I had a long discussion with my neighbor, who is a pharmasist. She said try selsun blue on my vitiligo. I doubt what I have is a fungal infection, but how do I get that diagnosed? Also, Nathalie, you mention changing your diet. Is there a good diet for vitiligo? And what do you know about salt playing a role in repigmenting? As I said, my story is over at “Around the World”, but I will be a very frequent visitor until I can get rid of these crazy white spots and then I’ll share all my info with everyone. I’m trying to wish them away. : ) hehehehe.
Hi Lisa,
LOL@ “I’m trying to wish them away. : )” … good one! Im pretty sure that my white spots are vitiligo, but i might just try the selsun blue thing to be sure.
This site http://vitiligo.50webs.com/ is where i found some ideas for dietary changes that helped a little girl repigment. i havent tried changing my diet, but i’ve had a few people write to tell me that it worked for them when combined with sunning and taking supplements.
i’m off to read the story you left earlier…i look forward to hearing from you again.
all the very best
nathalie
Nathalie, I love your support page and wanted to send you an email. How can I do that? I tried your contact page, but I don’t know, maybe I’m doing something wrong. Lisa
Hi Lisa,
Did you send an email through the contact page? If so, i will need to see what is wrong because i didn’t receive it.
My email is: nlp@vitiligocover.com
I tried mustard oil. It helps spreading the vitiligo, and darkens the spots. It also reduces the area, but I am yet to get rid of it. Have been using for last few weeks.
Best wishes to all
oops sorry, It helps prevent the spreading of vitiligo.
Hi mridul,how do you use this mustard oil?and do you buy this at a pharmacy?I would like to try it mybe it will work for me to.
I have vitiligo over nearly 50% of my skin surface with an onset of forty years ago (I’m 51). I have tried several treatments, including protopic and elidel which does indeed help some but you must use it for months to get results. My research seems to indicate not every treatment works for everyone. The best option would be too consult a dermatologist and begin treatments and if that fails start to look for your own options. By all means be wary of anyone or any website that claims they have a cure. If a cure was out there the entire medical community would be well aware of it by now. Humans have been suffering for thousands of years from vitiligo, I suspect if a true herbal cure existed it would have long been incorporated into modern medicine’s vitiligo treatment. Either way just beware of the fantastic claims made by so many. Having said that I would like to say this; the study done on the effect of black pepper (piperine) looks very promising. The claims are made by a well respected research facility who have published their results which means others can duplicate them if they wish.
Piperine is available from several sites on the internet, I’m not endorsing anyone so you can find them on your own. I am going to try it myself (I’ll be my own guinea pig) and here is my plan. At this point there appears to be two options, you can try the available pills or capsules or simply make your own concoction. I suggest crushing the pills or emptying the capsules and mixing with vaseline, then apply. As we all know vaseline is quite messy and it may be the best to apply at night. The other option is to purchase black pepper and make your own “medicine”, I plan to get whole black pepper corns, crush them, perhaps with a pepper mill, and boil with a small amount of water. Cool then strain and plan to keep in the fridge cause the elements can be degraded by sunlight. From the two studies that I have read one of them used crushed black pepper and boiled for ten minutes. I think more piperine would be available in a more usable form in peppercorns. In one of the studies piperine was applied to mice, five days a week, twice daily. I guess the mice and the researchers took the weekend off! A more aggressive approach would be to apply the crushed mixture, perhaps at night, and use the homemade remedy during the day. Sunlight helps to repigment quicker and more evenly but this is an area where you must use caution. The areas of vitiligo have no natural defense against the sun and they will burn easily and can be at risk for skin cancer. Also the piperine is degraded by the sun so the best bet would be to apply well in advance of any sun exposure and keep your time in the sun to an absolute minimum. Piperine is not some tanning compound to slaver on and then bake in the sun. The sun probably activates the melanine in the skin and piperine appears to arouse the melanine from its dormant state. I plan to be in the sun fifteen minutes a day, three days a week probably working on my lawn. I have looked on the internet for liquid piperine, if its available that may be ideal. Gotta go, have to get back to my studies (grad school), If you want the research I have uncovered you can email me. Good luck to all and wish me luck. Keep the faith…Ernie
hi ernest,
first off, well done with going to grad school. at 42, sometimes i feel like certain things are beyond my reach because of my age, but it’s people like you who bring me bring me back to reality with the knowledge that we are never too old for anything.
i look forward to your experiment updates.
best of luck to you,
nathalie
Hi Ernest,I will try this myself I am just worried what will happen if I apply this on my skin around my eyes this is a very sensitive area.
Hello Everyone, my name is Tone and i got this article from http://www.ohsu.edu/xd/about/news_events/news/vitiligo040908.cfm and thought i would share it with all of you. Enjoy!
Pepper Compound Could Aid Millions With Vitiligo
04/09/08 Portland, Ore.
OHSU and AdPharma, Inc. announce collaboration to develop promising topical agent for vitiligo, a skin pigmentation disorder that afflicts as many as a 100 million people worldwide
Oregon Health & Science University has licensed a family of compounds derived from black pepper extract – on which it owns the patents – to AdPharma, Inc. for potential pharmaceutical development. The compounds have shown potential in animal studies to be effective in treating vitiligo, a skin pigmentation disorder.
Vitiligo, which afflicts an estimated 100 million people worldwide, is characterized by the loss of pigment in affected areas of skin. It is the disease pop star Michael Jackson has publicly disclosed that he has. It is neither life-threatening nor contagious. But the sometimes unsightly white patches it causes produce emotional distress for many and often lead to social ostracism because of a widespread misperception that the condition is infectious.
An estimated 1 percent to 2 percent of the world’s population suffers from the malady. Current treatments, which rely on immunosuppression or ultraviolet radiation to stimulate repigmentation, are only partially effective, often producing a mottled appearance. Excessive ultraviolet (UV) radiation also poses the risk of skin cancer.
“Based on the animal studies we have done, these compounds, if proved safe in humans, promise far superior results in the treatment of vitiligo than current approaches,†said Amala Soumyanath, Ph.D., an associate professor of neurology, OHSU School of Medicine. “Vitiligo is a highly visible disease that can greatly affect patients psychologically and emotionally, even driving some to consider suicide. Any breakthrough in treating it would benefit a huge number of people around the world.â€
Soumyanath and her collaborators reported on the effects of their compounds in animals in a paper just published in the British Journal of Dermatology. But development of the concept dates back more than a decade. Soumyanath discovered – in research on vitiligo that she initiated at King’s College London – that piperine, the alkaloid in black pepper responsible for its pungency, stimulated the proliferation of melanocytes in cell cultures. Melanocytes are the cells that produce pigmentation in the skin. The researchers then designed and tested many synthetic piperine analogs and identified a number that produced the same result.
The group subsequently found that piperine and two of its analogs – tetrahydropiperine (THP) and a cyclohexyl derivative (RCHP) produced light, even pigmentation when applied to the skin of a poorly pigmented mouse model. When combined with UV radiation, the skin grew significantly darker and showed none of the patchiness caused by UV treatment alone. Moreover, skin pre-treated with a piperine compound required fewer UV exposures, thus lowering the cancer risk, and it took longer for the pigmentation to fade again than when UV alone was used.
Since coming to OHSU in 2002, Soumyanath has established new collaborations with scientific and clinical researchers to continue work on this project. “Dr. Soumyanath’s recent discoveries open up completely new and exciting treatment possibilities for those individuals affected by vitiligo,†said Andrew Blauvelt, M.D., professor of dermatology at OHSU and one of Soumyanath’s recent collaborators. “There is a huge unmet need for this disease because we have very few treatments to offer patients right now,†he noted.
OHSU acquired the patents to Soumyanath’s piperine compounds from King’s College London and BTG International Ltd. in 2006 and succeeded in finding a commercial partner, AdPharma, to advance the compounds through pharmaceutical development. Soumyanath has a financial interest in AdPharma. This potential conflict has been disclosed to the OHSU Conflict of Interest in Research committee for management.
AdPharma, a diverse pharmaceutical company headquartered in Arlington Heights, Ill., licenses promising compounds from scientists, universities and biotech companies and advances them through the clinical testing stage. “Our key strength is being able to identify, through our computer models and past experience, promising drugs which we can then drive through our strong development structure,†said Anil Sunkara, the company’s chief executive officer.
The next step before clinical trials can be undertaken, said Soumyanath, is to determine in animal models whether the repigmentation effects of piperine compounds is associated in any way with melanoma or other skin cancers. “From our mouse studies so far, it doesn’t appear that is the case,†she said, “and we are hopeful that more detailed research will bear this out. OHSU has ideal facilities and expertise for further preclinical and clinical studies, and we are excited to have the support of AdPharma as we move toward testing these compounds in human vitiligo.â€
About OHSU
Oregon Health & Science University is the state’s only health and research university, and its only academic health center. It is Portland’s largest employer and the fourth largest in Oregon (excluding government), with more than 12,400 employees. As a leader in research, OHSU earned $307 million in research funding in fiscal year 2007. OHSU serves as a catalyst for the region’s bioscience industry and is an incubator of discovery, averaging one new breakthrough or innovation every 2.7 days, with more than 4,100 research projects currently under way. OHSU disclosed 132 inventions in 2007 alone, and OHSU research has resulted in 33 startup companies since 2000, most of which are based in Oregon.
About AdPharma
AdPharma is a diverse pharmaceutical company engaged in the discovery, development and commercialization of small molecules, recombination proteins, delivery systems and devices addressing a wide array of therapeutic areas. Founded in 2006, the company’s management team combined has over 90 years of experience in the pharmaceutical industry and 15 years of information technology experience. Its founder and CEO, Anil Sunkara, has successfully launched 11 companies globally. “Our process,” explains Vivekananda Ramana, M.D., co-founder, COO and executive vice president, clinical affairs, for AdPharma, “not only identifies the most promising work taking place in many universities and labs, but also increases the likelihood that those projects can help improve the health of the people throughout the world. We are able to complement early stage research by picking up where many organizations leave-off.”
Hello everyone,
I just found this site and am so thankful I did. I’ve had Vitiligo for as long as I can remember. I’ve tried all sorts of topical creams and pills that made me nauseous all the time. I am so excited to try this piperine plan. I’m sick of the stares and having to give explainations to strangers. If this piperine helps, I will be so grateful. Good luck to everyone and especially Ernest.
I remember more than a year ago now a guy suggested that i ought to try black pepper (he meant eat it), of course back then i didn’t think it was worth consideration. How exactly is one suppose to use this, do i just mash it and stick it on face or what? GOD bless!
Thanks for this tip. I am definitely going to try this because I could really get enjoyment out of seeing my hands darker…that truly would be lovely. I’m going to restart my tanning bed and sit out in the sun since it’s warm here now.
Here is a tip from me. You can buy 100% non-diluted black pepper essential oil from http://www.aroma-pure.com. Please tell Jack the code word is Arne when you purchase. I’ll keep you informed.
One last thing from http://www.organicfacts.net/health-benefits/essential-oils/health-benefits-of-black-pepper-essential-oil.html
This is very informative and giving me ideas like taking Vitamin K…read on…
Health Benefits of Black Pepper Essential Oil Print E-mail
The health benefits of Black Pepper Essential Oil can be attributed to its properties like digestive, diaphoretic, carminative, aperient, anti spasmodic, anti rheumatic & anti arthritic, anti bacterial, anti oxidant etc.
lack Pepper is a condiment (spice) which is very common and popular worldwide. It is extensively used in culinary. It tastes hot and has a nice appetizing aroma. Black Pepper is the dried fruit of pepper plant, whose scientific name is Piper Nigrum. Once upon a time, it was considered sacred and even used as currency. It was so valuable that it was traded in exchange with gold (gold was considered cheaper to Black Pepper) and was one of the most priced trade items exported from India to the rest of the world. The main components of its essential oil are Limonene, Pinene, Myrcene, Phellandrene, Beta Caryophyllene, Beta Bisabolene, Sabinene, Linalol, Pinocarveol, Alpha Termineol, Camphene and Alpha Terpenene. Apart from them, black pepper is rich in minerals and vitamins like Calcium, Manganese, Iron, Vitamin-K, Beta Carotene, Phosphorus, Potassium and Selenium. Let us see what health benefits Black Pepper Oil has in store for us.
* Digestive: It is remarkably beneficial for digestion. It stimulates the whole digestive system, right from the salivary glands in the mouth to the large intestine, promoting secretion of digestive juices like acids and bile into the ingested food, thereby facilitating digestion. Black Pepper can be safely used as a spice to the food of those who are on a bland diet or otherwise forbidden to have chilies (those suffering from ulcer of the mouth of the digestive system or jaundice or extreme acidity are forbidden to consume chilies).
* Carminative: Black Pepper Oil is carminative and helps remove gases and prohibit gas formation in the stomach and in the intestines. It also helps inhibit bacteria which are responsible for formation of gas.
* Aperient: The Black Pepper oil has mild purgative properties and it is safe too, unlike other purgatives like Castor Oil. It helps clean the intestines and at the same time, cure infections in the digestive and the excretory system.
* Anti Spasmodic: It is an effective anti spasmodic and gives good relief in cases of cramps, muscles pulls, spasms, convulsions etc.
* Anti Rheumatic & Anti Arthritic: These are two of the best qualities of the Black Pepper oil. It is warming, stimulating and improves circulation, thereby giving immediate relief in rheumatism and arthritis, particularly in winters when the symptoms aggravate. It is also effective in removing toxins like uric acid from the blood, thereby benefiting people suffering from chronic rheumatism and arthritis, gout etc.
* Diaphoretic & Diuretic: Black Pepper oil, when ingested, increases sweating and urination. Both of these properties play an important role in removal of toxins from the body, clearing of the pores in skin and also disinfecting the body. Sweating and urinating help lose extra water and fat from the body, thus reducing weight, lowering blood pressure and making the body relaxed. These properties are also helpful in reducing inflammation.
* Anti Oxidant: This is yet another beneficial property of Black Pepper oil. It protects the body from damages done by oxidants (free radicals) and also helps repair them. It also delays adverse affects of aging such as vision loss, macular degeneration, wrinkling of skin, degeneration and loosening of muscles, loss in mobility of joints, nervous disorders, memory loss etc.
* Anti Bacterial: It has good anti bacterial properties and that too, without side effects. It is very effective in curing bacterial infections in mouth, colon, digestive system, urinary tract etc. It also disinfects food stuffs in which it is added and protects them from bacterial infections for long.
* Other Benefits: Black Pepper oil is rich in certain very useful minerals and vitamins too. For example, there is vitamin-A (Beta Carotene) in it, which is very beneficial for ocular health as well as is a very good anti oxidant. It has vitamin-K which is essential for maintaining proper circulatory and metabolic functions, muscles, bones etc. Then it has calcium, potassium and selenium. While calcium is good for bones and potassium for regulating blood pressure, selenium is essentially required for proper formation of bones, nails, hair, follicles and teeth and for proper functioning of brain.
Few Words of Caution: As such, there is nothing to be scared about Black Pepper oil, except that if taken in large quantity, it may cause uneasiness, unrest, vomiting, loose motions, irritation and inflammation of the intestines, sleeplessness etc. being hot and pungent. But there is nothing serious about these symptoms.
Blending: Black Pepper Oil can be blended with Lemon, Lime, Lavender, Sage, Sandalwood, Mandarin, Ylang-Ylang, Juniper, Bergamot, Clary Sage, Clove, Ginger, Geranium, Coriander, Grapefruit, Fennel and Frankincense Oil.
I happen to stumble onto this site while researching the piperine cure. I have just recently began to show white spots around my finger nails on both hands…this has been a true challenge for me. I am 49 years old and it is very relieving to read all of your blogs on this awful condition. I believe if we all pull together and continue to share info on this subject we can beat it…my added suggestion would be to go deep into yourself, for those who have faith in God and ask for the answers and cures to restore our pigmentation….very pleased with this site….Karen
I have had vitiligo for 4-5 months; I was initially prescribed Tacrolimus (Elidel) but decided against using it due to some safety doubts (FDA ‘black label’). I also decided not to use steriods for health reasons. Like you, I have also read about piperine. I have bought bioperine and used a mortar and pestle to grind it into a fine powder. I have used emu oil as a base (available in Australia). I am sure almond oil or another light vegetable oil might work to assist with absorption and bioavailability. I have started to use this home-made piperine cream in combination with a ‘pseudocatalase’ type cream: the piperine may stimulate better absorption of the manganese it contains. Of course the use of piperine has not been clinically tested on humans, so the possibility of side-effects is not known. On the other hand, it seems highly doubtful to me that a natural compound which we commonly ingest would be highly toxic if appied topically. The main side effect I experience with pipeine is a burning sensation that is quite typical I suppose of pepper! However, I am more willing to put up with a bit of irritation and take the unknown risk of piperine than I am willing to take risks associated with the other types of medication available. Anyway, while I expect that this might help over time, I am also reasonable in my expectations – repigmentation in vitiligo always seems to require plenty of patience. So far, I have some quite good repigmentation, but far from perfect. Jason.
Hi, I’ve found black pepper essential oil which I think I’m going to try mixing with a base oil. Are we supposed to get some sun after applying? (May be a problem living in the UK!!!) Also, has anyone tried Kalawalla – thought might try that. Am definitely going to do B12, Folic acid, Vit C etc. Good luck all!!
I am using 100 percent black pepper oil, no carrier oil at all. I surmise that the peperine is more accessible to my skin and I do get tingling but no burn. It feels like tiny needles. I just started this week.
Hi my friends. I am male, 26. I have had vitiligo for 4 years. At first, I find a very small round white spot in middle of my forehead. Dermatologists prescribed me with Meladinine, but it became larger and larger, inspite of the treatment. Fortunately, I found a retired doctor who stated firmly that he can stop it, even cancel it. I couldn’t believe. He prescribed me with DAPSONE (or DDS) 100 mg/day. Strangely, it became narrower and narrower and disappeared after about 7-8 months. My skin became normal. Then, whenever some other ones emerged, in face or in my “private organ”I immediately takes Dapsone. For 4 years, I have taken quite much, and now I am doing.Afraid of it possible side-effects, I want a faster (more efficient), safer therapy. So I will try black pepper. Who want to know more about the Dapsone Treatment, please email me. I may have some useful references for you. God bless all of us!
- Please Read:
Dapsone, a major component of an anti-vitiligo treatment regimen (Salafia A)
- Link:
http://www.aifo.it/english/resources/online/lml-archives/archive%202007.htm
I read about the piperine study that is going on. What about Bioperine a common derivative of piperine. This would have to be ingested as a supplement I assume.
Some thing else that has helped me with my vitiligo is a good quality spray tan. I use Neutrogena micro mist. It looks more natural for me and I wouldn’t feel comfortable wearing make up. I am able to spray it on a spot and spread it around. Good luck let me know if there is any thing else worth trying.
I started to use the black pepper oil directly on skin only 2 days ago. I will apply it twice per day with no exposure to sun being afraid of burn. I had vitiligo since 6 years but only one spot on my face, around the nails of both hands and 5 small (coin size)genital spots. I am a male 54 years old and I will inform you with the results after 6 weeks. Wish all of you the best luck.
As I stated I am using the black pepper oil 100% with no carrier oil and also the tanning bed. I turned red in all places and burned my inner thigh a bit too much but I think the process may be helping, just don’t want to say yet. It’s been two weeks, I think, and I’ve done it twice.
UPDATE: I got sunburned at first (two weeks ago, maybe on the 21st. Did it about two times and then, ouch! That hurt! And it prevented me from tanning until a few days ago. I had to wait until I was healed. I should be writing down the dates, but I’m not scientific enough.
Now, I don’t know what to think about the following: I wouldn’t rely on wishful thinking, so I won’t come up with any conclusions just yet. I had my friend look at my closely at all my spots before I began with the peperine and tanning bed.
As stated, I don’t know yet whether I should trust this procedure, but I had tiny pinhead spots of vit all along my chin and now they are completely gone. Easy, it could just be because of the tanning bed, I don’t know.
However, under my nose is a thin layer of brown as well as the corner of my lip; it used to be totally white here. I must say, though, that it is a little red as well. When I press my tongue inside my cheek at the corner of my lip where the vit is/was, it no longer turns pure white upon pressure. Good sign.
Inner thighs, smaller pure white macules (?) and more brown wash. Not sure if the freckles were there before. Is this the tanning bed or the peperine? I don’t know. My hands have not changed that I can see. Elbows, no change yet either.
So who knows…time will tell…
I just found this website and I have loved reading all the comments and support from everyone=) I am 35 years old and I have had vitilgo for 3 years now. It started on my hands first and I have a little around my mouth. It has recently showed up on my elbows and on my feet. I pray everyday for healing for myself and for everyone else who has this disease. I am fixing to start taking B12 and folic acid(I will everyone know if it helps). Today was the first time I have heard about using black pepper, please let me know if anyone has any success with that. I look forward to coming back to this webite=)
AD
What is your procedure? What have you mixed with the piperine to apply to the skin? Did you use Bioperine?
Nevermind I went back to your earlier statements and now my questions are answered, keep us updated this is interesting and it gives us hope.
I am hesitant to say this procedure is working. It will take some time to actually say that it has or has not. What I can say is that the tiny pinpoint vit spots have definitely gone away. The larger ones may have an even brown wash but I’m just not wanting to say that it is vitiligo leaving or just red brown from the tanning bed. I just don’t know yet. I will keep in touch.
One last thing…All the spots are really itching like crazy.
hey guys, im 23, live in uk, have had vitiligo for 5years and is slowly getting more pronounced! i have also tried all types of prescription meds, elidel, the shampoo and lots of steroid creams, also some chinese herbal remedies, all have failed or have stoped, steroids jus seemed to make it spread faster! any1 else find that? Heard about the pepper and also conidering applying ground peppercorns and vasaleine!! Hey anything naturals gota b worth a try!! summers coming, i dread short t shirts n vest tops!! hope someone can find us a cure, or even a good cover up, i find st tropez can provide good cover but messy to apply!! Good luck to everyone, glad i could share with you all, its reasuring to know im not alone! X
hey guys, im 23, live in uk, have had vitiligo for 5years and is slowly getting more pronounced! i have also tried all types of prescription meds, elidel, the shampoo and lots of steroid creams, also some chinese herbal remedies, all have failed or have stoped, steroids jus seemed to make it spread faster! any1 else find that? Heard about the pepper and also conidering applying ground peppercorns and vasaleine!! Hey anything naturals gota b worth a try!! summers coming, i dread short t shirts n vest tops!! hope someone can find us a cure, or even a good cover up, i find st tropez can provide good cover but messy to apply!! Good luck to everyone, glad i could share with you all, its reasuring to know im not alone! Xx
Hope all is well with everyone= ) Jade, I know what you mean with summer, I live in Florida so it feels like it’s always summer here…. My child plays soccer and I try to go and enjoy the games without worrying about my vitiligo getting worst. I do believe God is trying to teach me to love myself and not worry about what someone might think…… We all need to remember we are fearfully and wonderfully made=) Have A Blessed Day!
hi,
i am 35 years old, i have vitiligo since 17 years, my dad is doctor, i went to almost 20 different doctors in India and USA , I used all tretments, UVB nothing works , first time i read somany like me waiting for cure. is any good make up to cover white patches
Hi everyone –
I wanted to point out to people who are trying to use pepper corns etc., that it probably won’t work: piperine, a pepper extract, may be useful – just search for the product ‘bioperine’ on the Internet. I have actually found that it does darken the skin when you apply it with some kind of oil – flaxseed is best – even without sunlight. By the way, I think anyone using sunbeds should be very careful – skin cancer is far worse than vitiligo, and white skin is obviously easier to burn.
It might also be useful to take bioperine internally as it is supposed to assist the body to absorb minerals: here is a very interesting article on a possible approach to treating vitiligo with minerals and vitamins – http://www.wipo.int/pctdb/en/wo.jsp?WO=2004075849&IA=WO2004075849&DISPLAY=DE
My suggestion is to try multiple therapies, especially if you find conventional medicine (e.g. steroids, tacrolimus etc) ineffective or undesirable. That means using a good mineral and vitamin supplement in combination with bioperine, as well as using topical application of oils with mineral salts and/or bioperine. In addition, some people find supplementing their diet with Phenyalanine and Tyrosine (both protein supplements available from health food shops) useful.
This ‘combination’ therapy is what I am doing and I am slowly getting results. The annoying thing is that you have to take a handful of pills every day, plus rub in creams, and that can be impractical at times. It is also a little expensive. Also, improvement seems to very sporadic – i.e. fast repigmentation at times, followed by periods of no improvement.
I will definitely keep this forum posted on further information I find.
Jason.
Re: my last post, the protein is ‘Phenylalanine’ – i mispelled it earlier… J
Hi,
I have had vitilgo for 39 years. I have been taking burdick roout and bulpleureum herbal supplements for years now. I have had remarkable reuslts on my face but not much luck on my hands, elbows, armpits, knees and feet.
I am about to begin a new light therapy called EXTRAC laser from the dermatologist.
Will keep you posted.
UPDATE: My black pepper oil experiment failed. The color on my thighs is more white than it was before. The itch is almost unbearable at times. Nonetheless, I have lost color.
It may be working on my face, however, but only under the nose.
It is not working on my elbows or my hands.
That’s it.
Oh, inside my arms, it is working. These are the most current spots I have.
Vitiligo only covers maybe 5 percent of my whole body. If all my spots were concentrated to a particular section of my whole body, it would be the size of maybe a hand and a half being totally colorless. I have had vit for 15 years.
UPDATE: BLACK PEPPER EXPERIMENT IS WORKING!!!
I guess I gave up hoping to see some marked changed but I never stopped the process I was using but one day late last week, I got up and looked in the mirror and to my surprise I had dark freckles on the white spots on my face! My under arm spots are closing in! And I have some dots on my elbows. Although I dont see spots on my inner thighs, they’re just a flat wash of light brown. Hands, no change. Well, well, I guess I’ll keep this up.
What I think is happening is that the vitamins, Recouleur, along with everything else I’m doing is a ritual that is working. Just FYI…
hi jason.
you are correct, I just started using bioperine, but i don’t know how many times a day i have to apply, i am taking every day vitamin , folic acid and 3 days UVB treatment lets see if any change in color
Hey AD.. congratulations.. hope u keep re pigmenting so well!! it gives everyone with vitiligo hope here!! i am concidering using the oil and exposing 10 mins of sunshine a few times a week also taking vitamins.. especialy vitamin k & e… just curious how many times a week are u applying and tanning? are u applying the oil directly before u go on the sun bed? Ive spent years going to dematologists and am sick of being experimented on and photographed!!! Why not try this in the peace of our own homes!!
Hi Everyone, I am from Europe. I am exited about the peperine treatment results. I would like to ask you what you think about NOVITIL because in my country there are a lot of people offering it but I do not believe it works. I know it has been around for a few years but I have not read anything about it in your comments. Thansks Zd
HI again, I just found this page which seems to me quite interesting: http://www.jautoimdis.com/content/2/1/11
Hi everybody again, I would like to ask you what you think triggered you vit. In my case I think it must have been stress ( long term in relationship ) because very soon afterwards it started and I had never had any problems like this nor any related disease before. Thank you for your comments…
Hi Zdenek, I’m not sure what caused my vitiligo but, I was under alot of stress also at the time it started on my hands and face (that was 3 years ago). It is now on my elbows and feet. One of my friends from church told me about a homeopathic doctor and he told me to take vitamin b 12(1000mcg 2x a day) and folic acid(5mg 2x a day) which I have recently started taking for vitiligo and psoriasis. Most of all, I am praying and believing for God’s healing! Hope everyone has a beautiful day= )
I also was in a relationship where I was betrayed terribly and also my own mother betrayed me. To me vitiligo means betrayal. I’m getting over all of it though now…
yeah my stress was also from being hurt in a relationship, I got very depressed and even more so when the vitiligo started, I had never really heard about it and looking it up on the internet depressed me even more……. I always thought I handled stress well but I guess not…..
Hi hef07,do you only get this Dapsone in India?Iam living in Cape Town, South Africa.I am using folic acid and multi vitamins and also aplied psoriasis ointment on the white spots around my eyes and mouth.With a very good outcome,my white spot around my mouth perticularly is getting its coulor back.Please dont stop hoping for a cure for this white fire.Please I would like to know more about Dapsone!!!!!
Dear Russell !
Thank you for replying. I’m from VN. All about my therapy is: Dapsone 100mg/day, taken at a fixed time of days. That’s all, nothing else. It recover the area on my skin slowly. I just have some small spots, but often darken it with Dapsone (DSS, or Dyamino Dyphenyl Sunfol) 100mg. I often ask the doctor about the side-effects of the therapy, but he often say firmly that it’s safe. It often takes 1 year for a 1 square centimetre spot. Now I have a white spot on my forehead, and the “face” of my “private organ” .I have used Dapsone for 3 year, and stop the development of vitiligo, but always in a worry and hope. I have to work hard to forget vitiligo. Can you share me your therapy in more detailed.
Hey Ad, please, keep us updated about your repigmentation. Thanks
Zdenek ~ Under my nose is really filling in from inside the nostrils outward. The corner of my mouth is still light brown but no freckles like under my nose, there they are closing in on one another. I do see some action in my hands but really, really slight, but it does mean it’s working. My elbows are closing in to a small degree also. I look at my spots and know them well. Inside my thigh is browning slightly but that’s it for now.
I forgot to say that I really think that the peperine, tanning bed works and what pushes it is the Recouleur vitamins. I’m not sure if I told you I added that in after a month at my new protocol.
Hi Ad, thanks for the info. Lucky you ! Great, keep going and please let us know later again.
Hi to all again,
Do you guys think that the introduction of the new PEPERINE based medication can take as long as 10 years? Please, let us know if you knowÄ› more. Thanks a lot..
Thanks for the well-wishes…I use the tanning bed with the black pepper oil and I only stay in the bed for 2.5 on each side of my body. If I stay in longer I get burnt and it hurts like hell and then itches like crazy. I only use the bed only once or twice a week but mainly once. But the Recouleur vitamins seem to really kick it off. Yes, I am a bit more excited about the possibilities but hesitant in doing cartwheels at the aspect of all of my vit filling in. We’ll see!
Hi Ad, yesterday I bought the black pepper oil. I going to give it a try too. I would like to ask what color is your oil, mine is just transparent like water. I read that it is supposed to be yellowish or so. Thanks…
Anyone who wants to make up a cream using piperine can purchase bioperine from this supplier.
http://www.physicianformulas.com/store/scripts/prodview.asp?idproduct=308
It is not that expensive and seems to be delivered pretty quickly – took about 5 days to get from USA to Australia.
Jason.
I am interested in the relationship between vitiligo and emotional stress. It does apply to me as well. Seems to be a common theme. Then again, a lot of people have emotional stress these days, so it may just be a coincidence.
Does anyone have fatigue associated with vitiligo? I felt exhausted during the period that it emerged, and have been seeing a well qualified TCM (Traditional Chinese) doctor to see if I can improve my energy levels. They believe that the syndrome is caused by some sort of imbalance in the digestive and endocrine systems. It is really worth making sure that you stomach, kidneys, liver etc are all working well. The herbs they have prescribed me have certainly made me feel 100% healthier, energetic etc, even if it ultimaly doesn’t hlpe the vitiligo. I’ll keep you posted on this as well as the piperine. I am basically trying alternative treatments becausr the western ones seem to have side effects and risks that I am not interested in.
Enough from me for now. Jason.
Zdenek, my oil is clear also and I don’t know anything about yellowish but the one I am using seems to be working. Good luck! I believe the tanning bed and the black pepper oil is working in unison and the vitamins enhance the effect (Recouleur). On the vitamins, it’s my understanding that in people it’s going to work on the best it doesn’t take long to see pigment being produced. So I recommend that too. All my spots are either light brown or pink/red, which the pink/red is on my hands and I am hoping they will turn more brown in times to come.
Ad, sorry to bother you again. I found out that apart from black pepper oil there is also black pepper oleoresin. I searched for differences (especially the content of peprine )between the two and did not find much. Do you happen to know anything about it ?
Adenek, I hadn’t done so much research but I am impressed that you have! I only wanted to buy the most pure black pepper oil as I could so I could derive as much peperine as I could. I’m happy with my selection at the above-mentioned place where I bought it…no problem at all in contacting me ever.
Hi Ad, do you know how many percent of peperine your oil contains, please ? I found a store in Prague selling the oleoresin containing either 45 or 95 percent and I do not know which one to choose. I guess the stronger one provided it is not maybe too irritating. Thanks
P.S. The thing is the oil I bought does not say anything about the concentration of peperine.
and AD, do you have any experience with the eximer laser 308nm ? Unfortunately it is not available in my town yet but read a lot on the internet about it.
oops, excimer laser
Zdenek, you’re a great researcher! (smile) I can’t answer that question but if you do find out I would love to hear about it. My only concern was that the oil itself was only black pepper and nothing else added as a filler. So it is 100 percent from the black pepper seed. Now you are bringing in the world oleoresin which I am not sure about. If you can explain what that means, it would help me understand this conundrum.
I have no experience with excimer as it is out of my budget but have heard fantastic things about it. May if things get worse I will have to afford it. Thanks for the information and please let me know what you find out.
Ad, thanks. So far I only know that the difference is in the production process. And that in oleoresin they state the amount of peperine. I let you know if I find out something interesting.
excimer works for most people and results are very good. Try it for 3 weeks and you ll know if it works for you or not . i had patches on my elbows 4 x 9 cm and now only specks of white are left. Basically its the best treatment(if you are responsive) . if your patches about 20 % surface area or less then it is practical. if more of your body is involved then the full body chambers are more practical(NB-UVB ie Narrow Band Ultraviolet B). These chambers provide you with doses of NB-UVB at more or less the same wave length as the excimer. Excimer works at a wavelength of 308nm and those full body chambers at 311nm both stimulating the pigment cells. The laser assists in making the ultraviolet narrow band light penetrate deeper which has the ability so stimulate deeper seated melanocytes.
In my knowledge if your melanocytes are responsive Narrow band UVB then any of the treatments on nbuvb principle will work . That Inludes excimer as well .
Elbows and knees are good responsive areas to judge the efficacy of the treatment early.
all the best
Zeus
Thanks a lot Zeus.
hey zednek .the older the patch gets the tougher it has been to repigment it for me. And the larger it is, if not in an area which has hair follicles the tougher to repigment.eg. hands and feet. but again different people show different responses, some faster and some slower. Mysterious vitiligo. My suggestion start treament early and make your journey to repigmentation shorter. Dont ponder much about nbuvb. just try it and know for your self. i suggest you go to qualified dermatologist if you havent already been to get a sure shot diagnosis. i have seen people complaining about uvb not giving them results and when they go to a doc he tells them that they ve been getting treatment for the wrong thing.
that they dont even have vitiligo.
god bless take care.
Zeus
Zeus, thanks again, do you also apply anything on the patches while undergoing the light treatment ? Ad says he uses peperine oil and I am going to try it too. I have already tried gels recommended by my doctor but they did not work a bit- srange ( for ex: vitix, vitiskin, viitlan ). Looks like it is a good business for pharm. copmpanies. About 2 years ago I tried phototherapy uvb using vertical light tubes, about 25 sessions with no results. So I sometimes think it looks like it is not vitiligo but my doc assures me it is a stubborn one. I olny had a slight results on my hands using stereoid ointment. See you
Hi Ad, how are is your repigmentation going ? I have been searching everywhere to find out how much peperine is contained in black pepper oil and everytime I find some composition the articles mention many substancies but never saw peperine in the lists – weired. Do you think please you could ask somebody ( maybe in the store you bought at ) about it ? It is no rush! I am glad it works for you ! Thanks a lot
Zdenek, go to aroma-pure.com. There is a telephone number there. You can call him and ask him. Let me know what he says at your earliest convenience…Thanks!
Hi Ad, thanks, I have asked them by mail. And are you still going on with your treatment ? Can you tell me please about responses in your face ?
Hi Zdenek, as I stated earlier, my melanin is filling in on my nose with freckles. Now, as they fade out the whole area under my nose becomes “darker”, same with the corrner . I had gone out of the country, Calgary, and in that time I didn’t use the tanning bed for at least ten days. I’m thinking I need to get geared up with it again because maybe the fading of the freckles is indicative of me not using the tanning bed so I started that yesterday. Now, I did look at the oil and it is yellowish and not clear. What did you find out? Thanks, Zdenek!
sorry, same with the corner of my lip; it never had freckles there, just got darker and narrow. The tiny spots under at my chin area are still brown and no longer pinhead white spots. i just have to keep up with the tanning bed I think, the black pepper oil and the Recouleur vitamins.
There’s a new thing I want to try called Melagenina. I’m spelling it wrong, but a Cuban doctor about ten years ago said it works. It’s human baby placenta mixed in alcohol with calcium added. The problem was you couldn’t get it because of our trade practice with Cuba which I’ve read has now just changed so they sell it onine and on Ebay. At the melageninaplus.com, you can buy it for 120.00. I have purchased it and waiting for it to come. Do so research on it and let me know what you think. I’m pretty hyped about it right now.
I am South African and heard about black pepper on Wednesday. I went straight after work and bought 100% ground black pepper. I am mixing it with a bit of water and applying it directly on my vitiligo. I keep it on for about 30 minutes and are going to do this twice a day. Planning to apply direct sunlight with tanning lotion. Second day and I can see a difference. Wil keep you updated.
Hi Ad, thanks for the update. I know about the thing made in Cuba hopefully it will help too. But I do not know much about it only that some people here also want to get it. My oil is clear unfortunately compared to yours. The yellowish color indicates the presence of peperine. I try to get a different one. The oleoresin I have contains a lot of peprine but it is almost impossibe to spread on my skin since it is very glue like.
Zdenek, maybe you should heat the oil with some softer oil, like coconut or olive. Only on top of the stove, don’t microwave it. I think microwaving anything destroys the molecular make up. If the oleoresin is that thick and contains so much peperine, I wouldn’t give up on it.
Petrus, congratulations! I’m impressed. Not that I know any more than anyone here but I would mix the ground pepper with coconut oil or olive oil so it can seep in better in your skin, heating it the conventional way, not microwaving and storing it in a glass jar. I’m really happy for you!
Thanks Ad. Tell me, has the peperine actually worked for you? Are your vitiligo gone now?
Petrus, no, my vitiligo has not disappeared. It is more brown or some places have freckles and have shrunk. I’m still working on it although, yes, there is improvement.
Hi Ad, thanks for the advice, I will try to heat it up.
Also, I would like to ask you how you coped with the emotional stress before you started this repigmentation. I am asking because this year vit. appeared on my eyelids and a bit around my eyes appart from my chin and for some reason it is starting to stress me quite a lot. I try to cover it with tanning lotion but it still shows more or less. Do you also use any cover ?
Zdenek, I’m beginning to really like you (((hugs)))…PS, I am a woman. I noticed you referred to me as a man at some point but I am feminine (smile)
Now, vitiligo has been a very traumatic experience for me. I have also been told that I made too much of it, that I may have body dysmorphic syndrome because vitiligo once upon a time stopped my total life. I didn’t want to date because the majority of it was in my most feminine section and inner thighs. My doctor told me it could be a turn-on for some men and you know what? He was absolutely right when I gave myself a break (hehe).
But I do have it on my fingers, dots on the knuckles, about the size of pencil erasers, around my nail beds (some), my elbows and under my nose where it’s repigmenting and one corner of my lip where it’s gotten a bit darker overall. So I still have it for all to see. My repigmenting isn’t a miracle in that I am totally better, but I work on it and try different things ALL THE TIME.
I use in this order: Vitiligo Cover, Clarins dark bronzer. These two products work together fro my brown skin so at any time with or without makeup, the spots aren’t so bright. Then I put on SheLac by Benefit Cosmetics as an anchor (waterproofer too) for Smart Cover (very new product online) SheLac again, and Estee Lauder foundation over the spots on my face and hands. This lasts all day. Sometimes I don’t worry about my hands but in my profession I use them a lot and depending on how I feel about the client I may use it on my fingers.
As the years go by, I haven’t had a choice but to relax as much as I can over this. I go on dates without makeup (on my hands) because I feel like I am hiding something if I don’t. It give them an opportunity to at least notice it. Sometimes it takes them forever and I get antsy as if they are ignoring it. The worst part of dating is hiding the fact that I have it so I have to let it show. No one has ever found it grotesque and to my surprise no one has ever refused to date me because of it.
This used to really bother me because I thought everyone was lying trying to not hurt my feelings. I didn’t think anyone could like me, any guy, because of these spots. It was in my head so much that it actually prevented me from believing that I could ever be loved. I’m getting better.
Yes, vitiigo really kicked my butt in the social aspect. I am trying to get over it and have done so in a large respect but it still drives me crazy and is always on the top of the list of my problems. What I have decided to think of is: I don’t get any better than I am now in all aspects of life, so I am going to try to enjoy who I am now.
I have to think of my other visible aspects when dating. I am really a very pretty woman. I have a great personality and I am very smart and also very sensitive, caring and a great conversationalist. I try hard to catch myself when I get down about vitiligo because it can really bring me down and there is nothing that I can do about it. So it’s a struggle that I am overcoming as best as I can.
The best news I can give you is that I have learned that I am my biggest critic. People really don’t see me as the monster that I think I am. I have to remember that and I want you to do the same.
Love, AD
Hi AD, I am single and available. How about a date? I am in South Africa unfortunately.
Petrus, with such a strong name, I bet you weren’t named that accidentally! (smile)
Ad, Petrus is the Afrikaans name for Peter, meaning rock. Named after my father who was a rock in my life. In which country do you stay?
Petrus, yes, I am fully aware of what Petrus means, a beautiful name. That is why I say with a name like that, I am sure it wasn’t accidental. In America, in general, names don’t mean much, unfortunately. I am a northerner living in the south. Glad to be raised as a northerner but loving the south…easier way of life as compared to NYC.
Hi Ad, thank you very much for your nice and long answer. What a surprise you are a woman !I think I would definitely enjoy a hug from you !!! You sound to me like an inteligent and a sensitive person and on top of that as you say very pretty – that is an exeptional combination. I wish you luck in your life !
Thank you for your time it took you to describe your feelings about your vit. It is a relieve for me to read it. I think I am in a similar state as you were before. I do not feel like dating and lately even try to avoid meeting friends which is stupid because when I make myself go to see them then I am glad I went. I am a very sociable person. If you do not mind I can tell you a bit about myself. I am 43, of younger appearance, I think good – looking, and like sports and travelling and my profession is electronics which I like.
My vit. started shortly after my ex. wife and I returned from one year business trip in L.A. She worked there at school and I worked at a telecommunication company. It was 10 years ago. In the US our relationship began very stressful. So I think the cause must have been the stress and maybe too much sunshine as I spent a lot of time on the beach there.
These days I struggle with my emotions about vit.a lot so reading about all your feelings in detail makes me feel better.
I have a feeling it would be nice to meet you and talk to you someday. If you ever came to europe maybe on a business trip or something we could meet. Just curious, where in the US do you live ? I have toured part of Pensylvania, Texas and a lot in California.
Take care, Zdenek
Ad, do you also consider a possibility that maybe in a few years they could come up with something really working against vit. ? This is what I say to myself sometimes when I feel stressed about it. I think maybe I am also too much concerned about my look for a guy.
I understand your vit. in the face is stable, right ? Mine was almost stable up to now but this year it is worsening. I do not know if the reason could be that last summer I spent more time in the sun than before.
Hi Zdenek ~ There is so much more interest in vitiligo than ever before. Many doctors and scientists are giving it more attention so I am hopeful.
Yesterday I was at a client’s office and we were interviewing a doctor, emergency room physician, and guess what? He also had vitiligo. He was Japanese and he had a big spot on his cheek and his hands were white, more so than the other parts of his face. I saw him looking at mine on my hands and, well, we just knew we were kindred spirits without ever saying a word about it. We got along smashingly.
Yes, my vitiligo on my face is stable and I expect it to stay this way with no more new spots. About that doctor, you know, he still looked great. Yes, he had this big spot on his cheek but I didn’t find it offensive an no one else seemed to even notice it. So I say to myself that I must believe people when they tell me they do not pay attention to mine until I point it out to them.
I don’t think it’s from spending too much time in the sun because sunlight is curative to vitiligo…the rays are what make your melanin come alive. Rather, I think it is stress and diet that are the culprits because, when I started on the Recouleur, my freckling started almost immediately but, but, but I am wondering if and when I will get more freckling. Seems these freckles are disappearing that I have gained.
Vitiligo is such a big question mark. We’ll just have to find ways to love ourselves more and more each day. I am glad to talk to you as it helps me become more aware of my own issues with vitiligo. You are wonderful, Zdenek and Petrus too!
Oh, I forgot to say…One day I went out totally without makeup registering people for this activity here where I live…NO ONE NOT ONE PERSON was afraid of me!!! It was as if they didn’t even notice AT ALL. That was a fantastic and very freeing day for me! And I got lots of registrants!
My vitiligo only appeared about 10 years ago. Never worried about it until a friend, who I did not see for a long time, asked me what these marks on my hands are. My daughter also asked. Now I think girls are not interested in me because of it.
I applied pepper now for 8 days and cannot see it getting any better. Thanks for the tips on sunlight Ad. I will try to tan more but need to wait for sumer.
Hi Ad, thanks for your encouragement. As far as I understood right on one of the sites about black pepper I think it said that even using ground black pepper in food might help too. Have you read it anywhere as well ?
About sunbathing some people say that when they come back from their holiday on the beach some spots get better but sometimes new ones appears. So I guess vit. is really tricky. I have a similar experience too. My opinion is that sun is good, as you say for the stimulation, but it seems to me when it is too much it can impair melanocytes, who knows. There are so many different testemonials.
Also, have you ever tried this canadian product Novitil or any other ones ? I have tried a few and nothing really worked. Some doctors say if you stop worrying yourself about it sometimes it goes away by itself. But as we know its not that easy and I think it is exceptional.
Lets hope that finally they will think of something. Now I am also trying the black pepper oil mixed with the oleoresin on one spot.
Petrus, You have to keep going for at least 5 more weeks to see something.
Hey Jason, thanks for the info. How long did it take you to get some pigmentation using the cream made of bioperine? Did you apply it on the face too? Thanks
Now what is the difference between using black pepper and bioperine? Is there more peperine in bioperine than black pepper? I can’t imagine that being true.
Oh, finally, Zdenek…I had trouble responding because there was this black square preventing me from doing so for a while. Sorry. I can’t imagine ingesting black pepper or biopeperine would do any good. It gets digested and burned up with the digestive acids so how could that work? Usually, I would give things a try but ingesting large amounts of black pepper would only give me an upset stomach. I think the whole purpose of the pepper is to stimulate the cells underneath the skin.
I have some bad news. My freckles have gone away! They have mostly all dissipated. I’m sorry to see them leave. I thought about using the tanning bed more often but when I do, I itch so badly and get knots underneath my skin on my inner thighs and then they go down but it makes me kind of scared to feel those knots.
I’m a littled bummed out by it. I ordered the melagenina plus from the website of the same name and they were obviously a bogus site. I ordered it from paypal and when paypal inquired they sent a fake tracking number! Can you imagine??? So they gave me my complete refund back. Did you realize if you use paypal and don’t order thru ebay that you can lose your money completely? I wasnt aware of that but made a big stink about it and they refunded it. I’m thinking about reordering it on ebay from a seller that sells it in Germany. I just can’t find any real good reviews on it. What do you think???
Hope you are well. And Hi there, Petrus! (smile)
(((hugs)))
Now, my treatment works more slowly. I don’t know why. My doctor said that, it is because I work to hard with my mind. I’m an engineer now! What he said is true, now I am trying to live more simply and think less. Now, the doctor have prescribed me with: Dapsone 100mg/day, Forlic acid 1000mcg/day, Fe, B12 and Artiso (herb for better operation of liver). Thank! I have felt better and I am looking for any change!
Hi Ad, I am really sorry to hear about your new pigmentation slowly disappearing. I know how it feels because although I apply special creams on my face the pigmentation is slowly dissipating. It gives me a feeling of total hopelessness.
I have not found out anywhere how much peperine is contained in black pepper oil maybe unfortunately not much. Therefore perhaps your pigmentation was evoked only by the uv light and did not last long. Maybe the oleoresin could be more effective as it contains a lot. Maybe you could give it a try when you feel like it.
About the melagenina I only know that some people try it here. As soon as I hear something concrete I will let you know. Yes, it is really unbelievable what people can do for money I get to hear similar stories here too.
Now I found out something interesting about D3 vitamine cream. Look it up in google, seems to block the toxic processes in skin. Unfortunately for me I could find a store selling it here but I am going to ask my doctor about it. Also, my hope now is to try ointment Advantan on the face it is the only thing that worked a tiny bit on my hands and seemed to stop the progression.
Take care .
hello Zednek ,
been away for a while . Was real nice reading about your feelings about vitiligo. I’m in a similar position and stage emotionally. What ad says is very inspiring to me.Thanks ad.. well i ve been using narrow band uvb as i mentioned earlier and recently started the excimer . My knees have 99% healed though there is some hyperpigmentation which is more visible in daylight not so much other wise , which they say becomes normal in sometime. I really suggest to atleast try out Narrow band uvb (311 nm Philips TL-01 bulb). You did mention earlier that you ve tried uvb but try the narrow band out . THe excimer has slightly sped up my repigmentation . I have vitiligo on my hands , palms ,elbows,feet , soles and a few spots on my face (which keep coming and going) . I ve had vitiligo about 15 years. Didnt take it too seriously till about 3 years back till camoflage creams started becoming a hastle for me cuz it kept spreading slowly. And now just 3 months back i have started my treatment with nbuvb and excimer. My blood tests showed low vitamin b12 and and fol acid so my doc prescribed me supllements and b12 injections. I belive keeping your skin healthy , moisturised , well nourished(b12 and folic acid are very good for skin and many other things) really helps .
MY hands are showing a response at some places but very slowly. Though all this exposure to nbuvb has made the existing patches more noticable as i have tanned quite a bit which is supposed to become much lighter after i stop the phototherapy.
I apply an emolient once a day to keep the skin moisturised.
I read about the black pepper experiment and it really is convincing. i ‘m going to try the black pepper oil out and get back to you if anything sparks off.
Thats all from me today. THanks for listening.
HEy ad , petrus – have you tried nbuvb??
Hi Zeus, thanks for your advice and the description of your situation. About NBUVB I have taken about 25 sessions in hospital and the spots only turned red but really no pigmentation at all. Doctor told me to discontinue the treatment after the 25 s. because it showed no improvement. I wanted to continue but she said it would be useless so who knows.
Do you remember how many times it took you to see first repigmentation, please ? Yes I think moisturising is a good thing.
Did you experince any emotional stress 15 years ago before it started ? Is vit. in your family, please ? (my mom has it unfortunately)
looking forward to hearing from you !
My son has had vitiligo for about 3 years it is around one eye he has lost pigment in his eyelash and eye brow as well. In May 2008 we started narrow band UVB light treatments along with using Desonide cream about 2 weeks ago we finally noticed some repigmention. He goes twice a week even though I think if we could do the treatments 3-4 times weekly with a unit at home we might see more results. I know it is harder to get the eyebrow and eyelashes to come back . I have been dyeing them with roux eyelash and brow dye at home you can get this product a Sally’s beauty supply.
Cher, Yes I think this kind of oinment is good. I tried Advantan and saw improvements. I think the main thing is to get rid of inflammation which I think is the primary cause of pigmentation loss.
Ad, where are you ? How are you getting on with it?
Very nice site!
Hi all,
I have posted several times to this site (see above) and am continuing to trial piperine in an oil/beeswax base applied topically to treat vitiligo.
My vitiligo is limited to two large symmetrical patches in the inner thigh area.
During the first 4-5 weeks of using piperine (obtained on the Internet – see my other posts) the results were definitive, but very limited- i.e. some dots of repigmented skin around the hair follicles, like small freckles that would gradually expand in area.
3 weeks ago, I began to use Narrow Band UVB in combination with the piperine – i.e. using piperine on ‘off days’ in between UVB treatments, which I do at home with a hand held device (also easily purchased on the Internet, though not cheap – around $US750).
With piperine + NB UVB, there is really definite improvement. The skin tone has darkened quite quickly to the point that the vitiligo is hardly visible in soft light. In sunlight, the patches are much improved, though still quite noticeable.
I have decided to continue this therapy for another 4-6 weeks before reporting to this forum again. While I am now positive that there is improvement, I want to see how much more repigmentation I can achieve, and if there are any side-effects besides the moderate itchiness I do experience. Please note that the overall safety of this approach is not proven, though there is plenty of evidence that NB UVB is much safer than a sun bed, and that piperine is non-toxic (i.e. it can be taken internally).
At this point, my trial of these different approaches indicates that using piperine (NOT raw pepper) in combination with NB UVB (NOT a sunbed, which may increase skin cancer risk) offers substantial improvement in the condition.
I would encourage people with vitiligo to look carefully at NB UVB: it has brought about much faster improvement in my case.
I will extend this trial for another 4 weeks, then report again.
This is the most promising result I have had since I ‘got’ vitiligo about 9 months ago, so I think this could be some good news for some people, even though it does demand quite a bit of patience and persistence.
Jason Kaminski.
PS – in response to some new comments above:
1/
One of the ‘tricks’ seems to be to put sunblock on the non-affected areas of skin so that the NB UVB only affects the de-pigmented areas – then the areas of skin begin to match in tone after a while.
2/
I would suggest trialling NB UVB in combination with piperine (and/or vitamin/herbal remedies containing psoralens) even if NB UVB has failed on its own (i.e. as a monotherapy) before.
Jason.
Jason,
thanks a lot for your comments!
Can you tell me what web site you got the peperine from ? Zdenek
Hi everybody,
my doctor just offered me a light treatment using RED light. Please, does anybody have any experience with it or heard about it? Thanks
Hi, I have read that they are going to test the peperine on humans as early as end of this year.
NOVITIL – Hi guys, please do have any experience with this product ? Does it work ?
Please let me know. Thanks a lot
A few people have asked where to get ‘peperine’ from. Please note that the substance is called ‘piperine’ not ‘peperine.’
This forum does not allow recommendations of particular products, but you can find piperine on the net by searching for the term ‘piperine’ or ‘bioperine.’ It is cheap and easy to find.
It works best when applied after (not at the same time as) NB UVB light exposure.
I am still having markedly positive results, but you have to be patient: it has taken several weeks to see improvement!
Jason.
Jason, what is the ratio of bioperine to oil/beeswax you prepared? Do you think if the crushed bioperine was dissolved in alcohol then mixed with a carrier medium, it would be more readily absorbed? I’m thinking about making a super formulation with crushed bioperine and piperine oil but I need input from anyone on the potential usefullness of this approach. Good luck to you and everyone else, Okie.
Hi everyone, as having told you, I am using
DAPSONE for 100 mg/day, accompanied with Fe, forlic acid. It seems to work well with new patches, but hardly useless to old ones which appeared many years ago. Fortunately, I have only one old patch, but it is on my “male’s organ”. I am in two emotions, hopeful and anxious. At this time, I have recovered any new small one, but not that old one. I hope that some one may give me an advice. Now, I’m trying mental method including: relaxing practices and Yoga, because vitiligo may be related to mental health or the nerve factor. Atleast, it helps me feel better and happier even if it can’t defeat vitiligo. I think all of you should try it. I will update information frequently. Thanks, my friends!
Hi–
I’ve read your piperine thread and though I’m just a fumbler and not a scientist, my dad is a chemical engineer and I did a bunch of reading of updated stuff since you’ve posted. I’ve got repigging started after three treatments. I have gotten advice from articles, dad and aromatheraphy essential oil producers.
Here’s the scoop.
First, from the article I read:
Bioperine is NOT the same as piperine. One is from the green fruit of the pepper and while piperine is typically extracted from the seed of the pepper (the round pepper corns). Piperine does not have the burn factor of bioperine, and you don’t need to burn yourself with it. Eating black pepper or bioperine was not shown to increase pigmentation.
Secondly, the most effective solution for application was a “hot water” extraction. Essentially, similar to a tea. A cold water extraction can also be made. The difference between the water extractions and straight piperine has led researchers to postulate that some of the very effective ingredients may be water soluable. Even so, an essential oil of black pepper will contain the piperine in a relatively safe and standardized form and is used in massage oils and perfumes and cosmetics. Polo cologne contains up to six percent black pepper oil.
You do not need to worry about absorption. Piperine is used specifically to help other chemicals absorb into the skin. That’s why it is used in perfumes and in a manner in some one-spot flea treatments.
Buy a pharmaceutical grade essential oil of black pepper if you wish to use it and consider mixing with a cream base instead of another oil, which would cause the piperine to perhaps lay more on top of the skin and be greasy. I buy the 100 pct pure oil and the cream base from the same company. I plan to work on a water extract, but fear burning my skin and want something that is stable and consistent, so I know how much I am getting.
Side effects, for those who haven’t experimented. Tasting a cinnamon or clove like taste and smell for a long long time followed by a headache and possible mood alterations. Not good. A rule of thumb for essential oils told to me, if you put a drop on your cheek, you will taste it. If you put it anywhere else on your body and taste it, you have way too much in. I am currently using about .2 ml to one ounce of cream or less. Am told a typical good dose for used by aromatherapists is 8-10 drops pure pharmaceutical grade oil to one ounce base cream. Since piperine aids in absorption, fungi and other impurities can also be carried into your skin. Keep in mind athletes foot, etc. I add some myrrh oil, about .1ml per ounce as a cleanser/antiseptic. It also improves fragrance some. Then I add some ylang ylang, just a few drops to improve fragrance. I would never apply the black pepper oil directly, for sanitary and possibly overdosing problems. It is a powerful chemical used in insecticides. Read the MSDS datasheets on mice toxic amounts and what they died of–psychosis was part of it. Black pepper is also used to treat seizures, so you know it is strong.
piperine applied topically (injected transdermally) and I don’t remember if painted too, caused liver cancer which metasticized to other organs. While piperine seems to have some cancer fighting properties in some studies, it clearly is carcinogenic in larger doses.
Leave room in your formula for repeat doses. I have noticed a cumulative effect over time. Taking the weekend off is a good thing. Remember, most massage cream doses generally are not used every day and possess enough of a kick to increase circulation. So even the massage cream dose might be too high. Also, if you have a lot of vit, the dose may be too high. You definitely should not taste it.
Also, sun exposure was done immediately prior to applying cream so that the body was still in a “pigmenting” mood. I apply at night, but cannot go out in the sun.
Also, one study showed that piperine alters in many cases slows or prevents the breakdown of many medications. This is very important. So you need to research your medications and find out how long it takes them to break down and try to make sure you are not applying this during that time. Eaten black pepper does not have this effect.
Topical application of piperine seems to be more dangerous and powerful than eating it in many cases, so just because you can eat gobs of it or bioperine, doesn’t mean that topical application will be okay for you. And you can be allergic so you should always test.
All this said, I can tell you if you get too much black pepper oil on you, it will drive you nuts. It is very annoying. You can wash it off. It neutralizes astringents, like alcohol, though many pepper juice can be cleansed with vinigar. I don’t know if this works, I just scrubbed with soap and water and quit using it. I got a nasty aromatherapy headache and just was not real happy, felt a little dizzy, didn’t like it. So you don’t want that.
I wish some kind herbalist, aromatherapy person would try to make us a well measured preparation.
Also, be careful with your feet because of the athletes foot thing if you have it. Just try your formula on a clean spot.
The base ingredients I got from 100pctpureessentialoils.com and the support staff there was extremely helpful when I used too much. Their oil is pharmaceutical grade and really really strong. 8-10 drops is all you need per ounce or less. Their base cream is highly absorbent, the piperine helps, and contains other cleansing and healthy ingredients like aloe. Samples are about four bucks a four ounce jar and you can apply it very thin and rub in if need be. It is far superior to bath and body works in my opinion. The piperine will make it soak in fast. The black pepper oil, like their other essential oils comes in brown pharmaceutical bottles to prevent exposure to sunlight. I don’t work for them or anything, but I read about some people using bioperine pills and powdered piperine, which could be very easy to overdose on. The black pepper oil is widely used, not that it makes it safe, but there are at least readily available guidelines for its use in creams. Perhaps an oil would be better, I don’t know. The cream is less sloppy,non staining to my clothing and just easier for me to deal with. They also give you a bottle of fragrance oil with the cream for 3 dollars. Since ylang ylang is very expensive and I like it, I picked that. It seemed to go with the project. The myrrh oil I purchased elsewhere.
If you just don’t want to try this, I used to use an herbal formula called Schreiners herbal solution on my show horses when they had scars where the hair grew in white or sores that wouldn’t dry and heal, or I needed good healing. It contains myrrh, comfrey, and red pepper (capsaicin). it does burn, but many of my fellow horse people used it. I think the piperine is more effective, but I don’t really know. Schreiners has a web site and lists the original formula’s ingredients. You can buy it at any tack shop (horse equipment store).
I hope this helps. I’m glad people here are talking and wanting a solution like me. I’m not a professional, but I read a LOT before I tried it.
I can give you links to the updates if you want them or don’t have them. I also have some pictures of my progress.
On another note, if you test positive for TB, get treated with anti TB medication like Isoniazid, real medicine, if you can. TB can be a major factor and you can become very ill along with losing pigment. If you don’t know, get tested. In US, the health dept will do it. If you have dark patches along with the vitiligo, you need to see your doc and ask about an endocrinologist. Vitiligo is technically only the loss of pigment. TB can affect pigment because TB attacks the adrenals and endocrine system and the endocrine system controls the melanocyte stimulating hormone (MSH). Other diseases can cause problems too. Medical literature even talks about the patchy vitiligo and hyper pigmentation caused by adrenal dysfunction. You can have mild adrenal dysfunction and have major skin problems. Most docs don’t treat you with steroids until your adrenals are starting to fail, they do not know how to interpret the tests properly to treat milder adrenal conditions. And the endocrine system compensates, so bloodwork is not the be all end all. Alternative/natural hormone specialists that are doctors who treat milder conditions with natural hormones can help. Even my small town has more than one.
Sorry so long. Take care.
Could ‘curediwish’ please share the research articles cited? Some of the facts seem highly dubious to me. For the record, bioperine contains around 95% piperine. I would also doubt VERY MUCH and repigmentation aftr 3 applications of anything except paint! Vitiligo does not respond that rapidly in any literature review I have read. Please back up these claims with some evidence. Thanks. Jason.
Update for those interested – still getting good results from piperine (bioperine) applied after NB UVB exposure. I could send some photo evidence – is it possible to post photos to this site? Anyone? J.
HI all
Further to my last post – re: evidence of piperine studies – here (below) are four references that indicate that piperine is potentially beneficial in the treatment of cancer. I have not found any evidence AT ALL that there is any risk with using piperine topically. I really think people should back up what they are saying with references. By the way, there are 100s more studies indicating piperine is anti-mutogenic, anti-inflammatory etc etc – i.e. generally benefical to cellular health. J.
http://www.cancer.gov/Templates/drugdictionary.aspx?CdrID=440023
http://cat.inist.fr/?aModele=afficheN&cpsidt=14560337
http://www.ncbi.nlm.nih.gov/pubmed/18260741
http://journals.elsevierhealth.com/periodicals/ymai/medline/related/MDLN.9879661
Note the point that bioperine comes from the “fruit” of the black pepper. We use the corns or seeds in regular black pepper. The preparation is different than with the essential oil and the article notes that your body lacks the enzyme to create piperine by eating ground black pepper (piperine is in the seeds and fruit). So basically if you eat it, you are eating something that normally your body would not isolate, despite the claims of pepper’s use in medicine. It may be useful eaten for other ailments.
A good collection of information and research, including MSDS for it, is right here at this commericial vendors site (designed for chemists and product engineers and larger companies and doctors) and new research is listed below this link. Be sure to scroll all the way down and read the research at the bottom. The top is more about the history of pepper and its historical uses.
http://www.mdidea.com/products/new/new068.html
New Research is here:
http://www.mdidea.com/products/new/new068research.html
Even this non-technical sales type article indicates that eating ground black pepper does not extract piperine, and that eating bioperine is not something “natural” since your body would not normally metabolize it.
http://www.cochranfoundation.com/reports/piperin.htm
A quote from a cosmetic site:
“Classification of black pepper essential oil as a cosmetic ingredient
Piper nigrum fruit oil is the volatile oil distilled from the dried ripe fruit of Piper nigrum. It is classed as an essential oil and is used as a fragrance ingredient. It is known as black pepper oil, while Piper nigrum seed extract is extracted from the seeds of black pepper and classed as an essential oil and used as a fragrance ingredient.” from http://www.dermaxime.com/black-pepper.htm
Here’s some. How is the stinging going, are you having any from the bioperine? I considered buying the piperine powder, but the stuff is strong. I used the essential oil because I felt it was a safer approach and even that has its drawbacks because you can get too much on it is so strong. You might read about how essential oils are made and the water soluability of piperine. I probably am not getting as much as you, I don’t know.
I did have a rush of results at first, but I made my cream way to strong. I’ve quit for a while. I’m on a lot of medications so bioperine could effect my meds so much that I could have very bad results. I was looking for something safe.
The spots that repigmented most were on edges and small spots, with an overall pinkness on larger areas. Since I cannot do UVB, can only go outside briefly, that is also an issue.
Does your bioperine preparation burn when you put it on?
I’m not sure what all you wanted but there is a ton there and you have read closely because alot of it is really scientific.
In case my last post didn’t go due to the reproductive mutation information. I think I have a right to defend myself since Jason was obviously referring to me, which appeared in my inbox today.
Jason, I felt your post was a personal attack, inappropriate, and I will no longer be posting. I feel sorry for you that you are so bothered by your vitiligo that you will neglect the rest of your health and do incompetent research to convince others about the safety of piperine. If you choose to live in denial, that is fine. There is plenty of literature about the toxicity of piperine. Children have died eating a handful of black pepper, if you read fully the links I posted. There is also EPA toxicity data, etc.
I hope others will read fully the MDIdeas articles and scroll to the bottom and read the toxicity information and at the very end about who should and shouldn’t use black pepper at the end of the first MDIdeas link in my previous post.
There are many articles about carcinogenesis from piperine and the very effects you cite can be good or bad depending on a person’s health. The fact that piperine alters medication and causes reproductive problems for both genders, and drastically alters endocrine, hepatic, CNS and other body systems means that it can be very good and very bad. You do not bother to look at all the articles to make an informed opinion, but seek only research to support your belief. Hopefully others here will be careful and more objective. I had cited alot in my last post, hopefully it will appear and this one is deleted. It is not my responsibility to help another person do thorough research, but I will include this one from the MDideas new research links. I hope that people on medications, with potential health problems, or that simply are health conscious will take care to read and get help to understand the technical information. The research being done on piperine and other compounds is not being done so people like you and I can screw around with a toxic substance, or even so some adventurous doctor can experiment on patients, but so that new drugs can be designed that mimic the good aspects of piperine or derivatives while minimizing the bad effects for use in patients where the good effects outweigh any negative side effects. Arsenic cures cancer, however it has negative properties as well.
Now for the article, notice the mice below were painted with an extract of black pepper to induce carcinogenesis.
Carcinogenesis induced by black pepper (Piper nigrum) and modulated by vitamin A. Exp Pathol. 1990; 40(4):233-8 (ISSN: 0232-1513)
Shwaireb MH; Wrba H; el-Mofty MM; Dutter A
Zoology Department, Faculty of Science, Alexandria University, Egypt.
“Painting and feeding of mice with 2mg of an extract from black pepper on 3 days a week for 3 months results in a significant increase of the number of tumor-bearing mice. Tumor incidence is reduced in those groups of experimental animals receiving 5 or 10mg Vitamin A-palmitate twice weekly for 3 months by feeding or painting during and subsequent to application of pepper extract. Feeding of mice with powder of black pepper in diet (50g/3kg food) has no impact on carcinogenesis.” http://www.medscape.com/medline/abstract/2098270
I wish you all well. Please unsubscribe me.
Hi ‘curediwish’
I just wanted to take a moment to thank you for posting some information countering other posts. It’s so important, in any subject, for all sides to be shown. You brought to the forefront a valid point that I, too, have wondered about…the safety of pepper being applied topically. Many people don’t realize that most things applied topically can reach our bloodstream.
Honestly, after reading what Jason wrote, I don’t think it was a personal attack on you. I think he has found something that is working for him and wants to share it, but as you rightly pointed out, care must be taken when experimenting with any chemicals. Afterall, we don’t know the long term effects of piperine and neither do scientists.
Please consider staying with us here on this blog. Believe it or not, I have received a few hate emails from one particular person who visits this site, but keeping in touch and sharing with everyone here is far more important than avoiding one unhappy person. I am by no means comparing you and Jason to that situation, I just want you to see that adversity should inspire, not repel.
All the best,
Nathalie
I do not think what I wrote could be characterised as a ‘personal attack’, but I did find the response a bit OTT. All I asked for was citations, which have been provided, so thanks.
Looking at the data that ‘curediwish’ posted subsequently, I am happy with the risk profile of piperine. The study posted noted that piperine does NOT stimulate tumor growth – though other substances extracted from pepper may do. I am also not intending to ingest huge quantities of piperine at the levels force-fed to rats that subsequently died!
May I suggest a less hysterical dialogue on this subject? Those who wish to use piperine do so at their own risk, obviously.
Jason.
Jason misread. Black pepper extract, which contains piperine is carcinogenic when applied topically as the article below states:
Carcinogenesis induced by black pepper (Piper nigrum) and modulated by vitamin A. Exp Pathol. 1990; 40(4):233-8 (ISSN: 0232-1513)
Shwaireb MH; Wrba H; el-Mofty MM; Dutter A
Zoology Department, Faculty of Science, Alexandria University, Egypt.
“Painting and feeding of mice with 2mg of an extract from black pepper on 3 days a week for 3 months results in a significant increase of the number of tumor-bearing mice. Tumor incidence is reduced in those groups of experimental animals receiving 5 or 10mg Vitamin A-palmitate twice weekly for 3 months by feeding or painting during and subsequent to application of pepper extract. Feeding of mice with powder of black pepper in diet (50g/3kg food) has no impact on carcinogenesis.†http://www.medscape.com/medline/abstract/2098270
Since eating black pepper does not cause an increase in tumors, then something in the extract, like piperine, that we do not metabolize when we eat black pepper on food, is the culprit, they are implying. Further studies show that eating piperine does cause a marked increase in tumors, which can be reversed with limonene, another compound in black extract.
Thanks Nathalie. You have been nothing but kind. Here’s the study again that clearly shows that black pepper extract, which contains piperine, is carcinogenic, once again to set the record straight. “Painting” means applying it topically. The difference between black pepper extract and powdered black pepper is that the extract contains substances that our “gut” would not get from eating powdered black pepper, like piperine and others. Pharmaceutical grade essential oils and extracts are very very very strong.
I have had to cut back my application because it was increasing the side effects of the medications I take. It might also cause problems for others with liver problems or who take medicines, and that is my concern. Jason’s happiness at what he believes is a new cure does not absolve his responsibility if someone gets hurt trying this. I’ve warned people about the potential problems and am looking at discontinuing due to bad side effects and will wait for the experts to come up with something that is both safe and effective. I was very ill once and someone like Jason tried to get me to take some herbal compound that would have killed me given my condition. He is only considering his own condition and how it is working for him. He may be fairly healthy other than vitiligo, though he will find that piperine does have an effect on reproduction and mutation of fetuses as well. That this happens at a high dose for a short time does not bode well for long term studies.
While most people may have been told that vitiligo is a harmless condition that is simply a problem with pigmentation, many physicians feel otherwise and recognize it as a significant sign of possibly undiagnosed illness or autoimmune conditions. I worry that someone might wander onto this site and really get hurt trying something like this. Anyone using the essential oils must know it’s really strong and easy to apply too much, since many of us who would be most likely to try something like this have extensive vitiligo, so we end up using more cream.
My dad has been a chemist all his life and he’s made it clear to me that just because something exists in nature doesn’t mean its any safer than something concocted in a lab, after all, that’s where chemists get their ingredients from.
I simply ask you this, if someone tried this and was on blood pressure medication, and it increased the level of their blood pressure medication five-fold and they went into shock, or even just had trouble staying awake at the wheel, and got in a wreck and died maybe even killing someone else, is Jason’s happiness at HIS new discovery, is his ego, worth that? If he were my son, I’d be ashamed. Sorry Nathali, but this post is way too flaky and like beating my head against stupid. I’m done.
Hi all –
There is a comprehensive study of Piperine + UV treatment for vitiligo at http://findarticles.com/p/articles/mi_qa3931/is_200611/ai_n17192582
I am continuing to apply piperine following (not before)UVB light exposure 2-3 times a week with encouraging results. There is quite noticeable improvement, including some areas of about 70-80% repigmentation. Overall, I’d estimate a 30-40% improvement. There is moderate generalised darkening of the white skin, and some ’spots’ of pigmentation that look like large freckles, but there also seems to be a much more dramatic ‘filling in’ effect – i.e. the repigmented areas are spreading, sometimes quite quickly – i.e. over days rather than weeks.
I have been using UVB + piperine now for around 2 months. I had been using piperine without UVB for a couple of months before that, but there was very little improvement. I am absolutely sure that that the two need to be used in combination to get worthwhile results.
Obviously this is all ‘at my own risk’ as discussed earlier, but I do not have any negative side effects to report so far, except slight/occasional itchiness.
I have decided to continue to use this treatment for another 2-3 months, with some ‘rest periods’ of up to a week. I find that rest periods do in fact promote progress rather than diminish it.
Is anyone else having any similar experience? I’d be interested to hear.
Jason.
I would like to let ‘curediwish’ know that statements such as ” if he were my son, I’d be ashamed” indicate to me that she/he is a complete fruit loop. In terms of risk, I understand, as does everyone, that there is risk involved in most treatments. Indeed, people have died from drinking too much WATER over a short period. This does not make drinking water dangerous in general. Piperine is widely marketed as a supplement – as such, it is not my ‘ego’ involved at all, but the health industry, which freely sells this product all over the world.
Again, everyone does what they do at their own risk, all I am doing is reporting my experience. I think ‘curediwish’ needs to take a chill pill.
Bye for now. Jason.
Hi again,
On the topic of piperine and potential risk of carcinogenisis, ‘curediwish’ has not read carefully enough. The study cited by ‘curediwish’ clearly indicates that it is NOT piperine, but another pepper constituent (methylcholanthrene) that is risky. The full abstract is cited below. In other words, read the fine print!
Piperine has actually been studied for its anti-tumor/anti-cancer properties – there are many articles (i have found literally hundreds) supporting this hypothesis – a few are cited below FYR.
Abstract re: Carcinogenic Pepper Extract -(methylcolanthrine):
In mice, injection of safrole, tannic acid or methylcholanthrene (MCA) during the preweaning period induced tumors in different organs. Safrole and tannic acid (constituents of black pepper) were weak carcinogens when compared with MCA which was used as a carcinogenic control substance. Force feeding of d-limonene (one of the pepper terpenoids) for a long time to the mice which were injected with any of the above 3 substances reduced their carcinogenic activity, while force feeding of piperine (one of black pepper alkaloids) was ineffective.
Articles Indicating use of Piperine as an anti-Cancer agent:
http://www.ncbi.nlm.nih.gov/pubmed/9879661
http://cat.inist.fr/?aModele=afficheN&cpsidt=15443153
http://www.ingentaconnect.com/content/tandf/bfsn/2007/00000047/00000008/art00004;jsessionid=14wcco04wruul.alexandra?format=print
Jason.
I’d used black pepper after I read this article.
A friend of mine told me the same, it will be at least 10 ears before it can be applied to human body. We can’t wait for that long. My husband has vitiligo. We’ve tried all different ways before we tried this one.
I’ve been thinking how to apply the black pepper powder onto skin. I’ve heard about using fresh ginger. So I mixed the black pepper powder with liquid ginger and applied it to a new grown vitiligo patch. When I started, there are two new grown ones on my husband’s back. I applied to one of them. After six weeks, I felt tired and stopped to do it.
It is been 5 months since we first start to use it. Even we’d stopped. The one had been applied pepper and Ginger still have not changed to whole white, but the one next to it has been totally white.
Applying ginger is one of the traditional chinese treatment. Hope our story can be of a little bit help.
Meg have you tried Narrow Band UVB therapy?
Hi Jason,
Thank you so very much for sharing your Expereince with us. I am very grateful to you and everyone who are sharing thier vauluble expereince here ( Ad, Zdenek,Ernest, hef07, Russell and to all those who have posted here)
Jason, do you have photos of your vitiligo before and after going through your current treatment (NB UVB exposure + piperine) and do you mind sharing them with me?
i know this is very personal and you may not be comfortable sharing, if that’s the case, its Okay and i completly respect your privacy.
Thanks once again
Hi – I have had a few requests for updates on my post. I am now comfortable reporting undoubted improvement in my condition using Narrow Band UVB with piperine.
Please note that progress was unsatisfactory until I started using NB UVB – i.e. piperine alone was pretty ineffective. I saw some signs of improvement over the first 12 weeks, but much faster and more obvious progress when combined with NB UVB over the past (approximately) 8 weeks.
This is because piperine stimulates melancyte proliferation, but does not initiate melanin synthesis.
I make a cream at home using a commercially available piperine product (Important: I do NOT use pepper, or pepper oil, which is probably ineffective and may have unwanted side effects). I apply no more than 15mg of piperine in a flaxseed oil/beeswax base 1-2 x per day between (NOT at the same time as) NB UVB home phototherapy sessions.
In conjunction, I am also taking a normal multivitamin tablet containing b-group vitamins, zinc, copper, magnesium and other minerals once a day. I also maintain a healthy diet with high levels of antioxidants -e.g. spirulina etc.
I have to say, this regime is quite difficult to keep up. I have localised areas of vitiligo, so it is not too difficult, but it may be hard to sustain if the vitiligo is widespread or around the eyes etc. Mine is symmetrical/localised in the inner thigh region and slightly in evidence below the eyes. I first noticed vitiligo (though I didn’t know what it was!) almost exactly a year ago.
The areas of repigmentation are quite obvious. One side of my body is responding better than the other. On one leg, the repigmentation is already cosmetically successful from my point of view – but the other side is still ’spotty,’ so not cosmetically successful yet.
Again, there has been considerable (sometimes irrational) debate about potential risks. I have personally assessed the risks of NB UVB and piperine, and suggest each person does the same to assess their own willingness to trial this – see my previous posts and:
http://www.sciencelab.com/xMSDS-Piperine-9926579
http://www.smso.net/Piperine
There are many studies of NB UVB phototherapy on the Web.
Give me another 4-8 weeks, and I’ll post again, including detailed information, photos etc.
Sorry to be cautious, but I don’t want to post information that I need to retract – I want to be sure of what I am saying. I also do not wish to come under attack as I have recently for posting this information.
Jason.
Jason,
No. I did not use it. I had read from newspaper saying someone had been using the UVB by themselves. I believe it will be a more sufficient way.
My husband had been using it about 6 years before. Maybe that is an old styles one. It is quite painful because each time after the treatment, he had been scratching the treated area for weeks and applying pain-release cream because of the burn. It proved to be useful because most of the treated area were growing slowly than other area. BUt it would not stop the new grown ones in other area( definitly not).
Another reason is the possibility of skin cancer. I have read from the report to apply black peper would reduce the time for UVB treatment and then reduce the risk of skin cancer. We are looking forward to the formal release of the treatment report.
Hi Jason,
I am so happy for you, I am really excited this is working for you. Thank you so much for sharing this, this will help so many people here (obviously at our OWN risk)
I honestly just feel good inside me knowing this is working for you, gives me a hope.
Would really be interested in more details and photos of the before /after progress.
Could you please elobrate more on why do u think it is bit more difficult to treat if vit is under the eye
Thanks a million
Jason, I have been using piperine in a topical skin moisturizing lotion (30 mg in one once of lotion) once a day for the past 8 weeks. I have fairly extensive vitiligo on my lower face, neck, elbows, hands, lower legs and feet. Since I am a very lightly pigmented person, this has not been a big problem cosmetically, and is only really noticible when I get significant tanning from sun exposure. I have noticed a significant amount of repigmentation on my face and neck, mostly uniform in nature. On my elbows, hands and feet, I have developed more patchy areas of repigmentation, which are slowly growing in size. I’ve also been taking oral ginko capsules, 120 mg a day, and oral L-phenylalanine, 1000 mg per day. I haven’t used any phototherapy, other than to be outside in sunlight with 15 spf sunscreen on.
I agree with you that it’s a bother to apply lotion to all these areas on a daily basis, but not any worse than daily skin care if you suffer from dry skin.
So far, I’m happy with the results, and feel that it’s less likely to be carcinogenic than UV-B therapy. Remember, black pepper has been consumed in food for thousands of years, and is ubiquitous in the US, (check out those free paper packages at your fast food restaurant). In comparison with the current medically approved treatments, like PUVA, immune modulators, steroids, lasers, and surgery, pepper extract seems pretty innocuous.
Hi larrysyr
Thanks for sharing, this is fantastic news, so far only 2 people have shared their expereince with Piperine in this forum, yourself and jason and both of you have positive results.
Could you share more info on what signifact amount is , i.e how many % of your face neck is repigmented.
I am also interested to know if this repigmentation is permenent or it looses pigmentation again after a while, or an approximate time of how long is the repigmentation sustanable without continious therapy.
I guess this question is too early to ask since you guys have just started the therapy, but if you have any info on this, please share it.
Once again Thanks a million for sharing.
Hussainy, I don’t know, because I have only been doing this 2 months, but I assume that the repigmentation may go away gradually if I discontinue the piperine, because if vitiligo is autoimmune in nature, my body will continue to attack my melanocytes. It’s also possible that ginko and l-phenylalanine are also helping with this problem. All in all, it’s an experiment. I’d say I’ve gained about 50% repigmentation of my neck and feet. Spots on my face are much less visible. My hands seem to be the most resistent, although now it looks like I have a lot of freckles on them, before I had pigmentation only over the knuckles. I think that the results you get may be partially determined by your overall pattern and degree of pigmentation. I have been slathering this lotion all over the place, and noticed that the areas that don’t have vitiligo are also getting tanner looking, which isn’t actually helpful, because it makes the vilitigo patches look whiter in comparison. I’m hoping that the areas with vitiligo will catch up with the rest of my body, however. I would not apply piperine near your eyes, because it’s an irritant. Getting a little on the edge of my mouth has convinced me of this. It may not be appropriate for application near any mucous membranes (including genital use).
Hi larrysyr ,
Thanks for the clarification, much appreciated
I hope this piperine study and your experiments are successfull and sustainable. Its big hope for everyone who have vit.
I agree with you, the repigmentation will depend from person to person.
In relation to if the repigmentation being sustainable is a big question, since vit may or may not effect the whole body, though its autoimmune in nature, for some people it does not attack thier whole body, based on this asumption i wonder if our auto imune system will detect the previously attacked area is re pigmented and should it attack it again ? If i am not making sense, please excuseme.
I think about it alot, i really wish , hope and pray this piperine research is the answer to Vit.
Thanks once again please keep us posted with any further developments.
Regards
Hussainy
Does anyone know where we can fine piperine in South Afrixa, we live the Eastern Cape.
Thanks
Thank you so much for caring!
You are right about that also, it only cures fungal infections that looks exactly like vitiligo! Ummm, has anyone gotten aby blood tests taken to see if they are low on B12, or anything else like that?
Yoga is a good stress reliever!
I had vitiligo and was treated with PRESCRIPTION SELSUN shampoo.
I read this and found very interesting as I met a woman in a boat trip and she told me that she had vitiligo also disappear with using using selsun blue dandruff shampoo. I have been doing it for 2 months but just waited 5 minutes during my shower. I will aplly it and leave over nights just to try to see if there is something change as it doesn’t seem just a coincidence to me after reading this. The other interesting thing is dapsone. As I was searching on it and found it also being used to treat behcet disease (my mom has it). It made me believe there can be a link between these two immun system realted skin disease. We both had kidney infections and just only two of us has a skin problem in our family history. I think adrenal gland dysfunction is highly possible for both of us. I am very enthusiastic, smiley also active person just feeling so exhausted quickly. I have been thinking on this so went to an endocrinologist to test my system. He found my energy, vitamins, sex hormones, seratonin levels are incredably low but high level cortizon. Cortizon stimulation is adrenal gland response also I found pineal gland can cause hormonal dysfunctions. I believe vitiligo is all about endocrine system problem, caused by glandular dysfunction (liver,thyroids,adrenal gland,pineal,etc..)results lack of hormones also vit. deficiencies such like copper, zinc, iron, folic acit, vit. B.. There must be something to balance the glandular system what would give us long lasting success maybe even a cure..
My Best,
Sermin
Hi all,
I am 32 and had suffered from vitiligo for 3 years+. I had widely spread vitiligo on hand, body and leg. I had undergo intensive phototherapy. Some colour did come back on selective parts in a very slow manner but till now i still had a big patch on hand, leg and body
After reading this web-site i would like to try out piperine and selsun shampoo. Can anyone tell me where to buy selsun shampoo and where to get piperine oil in singapore?
Hi there Vitiligo girl,I have heard about selsun shampoo,I used to wash my hair with it for my spirisis and it work very well I never used it for my vitiligo,Generally you can purchase it from a pharmacy or supermaket here in South Africa.hope you find it and it will help you and please try you best to be positive about it,and you will see positive things will happen.
Hi Clive from South Africa ,Im living in Cape Town Iam also looking where I can find black papirine.I have joined a Vitiligo group,it was a great experience meeting other people with Vit. and talking about it openly,the group just started and we want more people to join us if afected by this skin condition.
Hi Russell,
I am from singapore so i do not think i will be attending this cool meeting. I just went to the phamacy to buy folic acid which after seeing alot of website that this is useful for vitiligo people. I had been taking B12 and undergoing Phototherapy. I would say that after taking vitamin B12 more repigment happen then i had not taken. Do give it a try.
Oral dose maybe not good enough because of our systems are suspected deficiency of using the vitamins from food we intake.I know someone do vit.B 12 shots what works greater than oral vit. B12. I am sure copper makes huge difference as well. If you take zinc you should have copper as well to balance them, zinc lower the eficiency of copper and copper gives color to hair and skin. It is available together which is the best in some products like NOW (brand name) zinc-copper-combined in a balanced formula.
Hi Sermin,
where can get B12 shot? In singapore? What supplement copper?
Hi Jovis I am on Folic acid and B12.Since I started not to stress so much and enjoy every moment I started to repigment under my left eye and on my chin,so I think it help not to stress and worry you.Sunlight plays a major roll.I dont have any new spots.I dont drink alcohol anymore.Every night I look in the mirror looking for new developments,and there is positive results, my spots are under control and that makes me feel good and give me a sence of hope that it will fully have its normal color.I used to put makeup on but since 2 months ago I have stopped I want people to see me and understand that its only a skin condition.I know for some people have deffrent ways of handeling vitiligo.
Hi everyone!
I am an Arabic girl living in America. I have had vitiligo since I was 5 years old. My father also has vitiligo. It was just in my knee then this year it started showing up in different places. In our country we have people with successful stories. One or two got ride of vitiligo by drinking one cup of warm water+ have lemon juice+ 3spoons of honey. Drink it every morning . You will see the results after six months and after one year you will be fine. I know it is easy. I tried to keep on drinking it but I am lazy. Another story, is to drink pure carrot juice once or twice a day. A third story, three or four persons got rid of vitiligo because they take a herb called Atmanta. There are many remedies for vitiligo if you want more tell me.I have a question!how can I make black pepper for viti?is it with water or oil?
Hi Arabian Girl,
Where can we buy this herb called atmanta? Also maybe you can share what other remedies is available
Hi Jovis
It is in Egypt. The brand name is Hazar. It has a strong taste so they make it in a form of capsules. It is the best remedy I have ever heard about for vitiligo. Other remedies are mix yelow sulfur with apple cedar and chopped garlic then apply it on the spots every day.You see results in one month but it is not for sensitive skin. Another one is to wet the spot with water then put some sulfur powder on this wet area. Olive oil with psoralea powder (ground the seeds).It is amazing. No one told me how to make the black pepper paste?
Hi Jovis,
You need to get shots from a doctor or pharmaciest. You should ask about it as it is different regulation in many countries. In my country I could even shot to myself but in USA only doctors can do. Copper is an elements supplement like zinc fe or magnesium. I just began to take vit,b 12 orally because I can not go to doctor for shots as I still can not work here waiting for my paperwork, folic acid and sun bathing sometimes. I take copper-zinc sometimes too. I don’t know if these would make some difference maybe just a little but I will share here. Piperine looks interesting as well.Lemon juice and honey in warm water I heard before just I can not recall where.Atmanta sound is interesting too just don’t know how to find it. Good luck for all..
Sermin
Dear Jason,
Can we please get an update
Thanks
HI Jason, its almost 3 months now, eagerly awaiting for your updates
Many thanks
Can someone tell me where they purchased materials to try UVB light treatments from home? I just found this forum and appreciate everyone in their pursuit of finding relief for vit.
You can purchase narrowband UVB with a prescription through your doctor’s office.
Or, you can go to Ebay and purchase a narrowband UVB light.
Narrowband UVB has worked really well for me.
i have had vitiligo since i was very young, it is very frustrating and i am wanting to try the piperine oil but want to know if i can buy it in a store. i live in denver colorado if anyone knows where to buy it here i would appreciate your info as i cannot find this info on the computer.this is a great site very informative and is giving me much hope. thanks
Hi all,
I promised to send an update on my trial of vitiligo treatment using NB UVB light followed by application of piperine suspended in a vegetable oil. I have been using this treatment 1 – 2x per week, not every second day as is normally recommended. I started doing this around 6 months ago.
So that all the facts are ‘on the table,’ I should add that I occasionally take the recommended vitamin/herbal supplements (Vitamin B + psoralen-containing herbs) as well as applying mineral salts directly to the skin from time to time – e.g. dead sea mud.
I can best describe progress as ’satisfactory.’ The improvement is definitive, but gradual. I estimate that I have achieved complete repigmentation (between the thighs) in 40-50% of the skin area. I have achieved moderate repigmentation (including freckling) over an additional 20-30% of the skin area. About 20-30% of the skin has not repigmented back to normal skin tone, though it has become a little darker.
From a cosmetic perspective, the result is pleasing, but not ideal. The general pattern of progress is for brown spots to appear, then for the spots to merge into an even area of normally pigmented skin. The spottiness is not appealing from a cosmetic perspective. On the other hand, the reduction in the size of the affected area is pleasing, and the general darkening of the skin means that the vitiligo is not really visible in dim light – e.g. in reduced light inside a room. Pior to trying this treatment, the skin was so white that it was visible even in very dim light.
Overall, I think this treatment is worth pursuing if the vitiligo occurs on an area of the body that is limited and if it is in a convenient position for light exposure. The progress is gradual, so patience and perseverance is definitely required.
I am going to continue to treat myself in this way for another 6 months to see if the repigmentation continues to 100% of the skin area. I am only using UVB once or twice a week so it’s not too onerous. I limit exposure to 3.5 minutes for each patch of vitiligo and only apply the piperine on every second day.
In summary, I think that:
- Using several treatment strategies in moderation (as I have done) has not had any apparent side effects, but the risk of doing so is NOT KNOWN – i.e. although my research indicates that the treatment I describe here is relatively safe, each person chooses what risk they are prepared to take in trialling different therapies
- NB UVB is undoubtedly the most important factor in getting good results: there was little improvement before I started using NB UVB
- Piperine MAY play a part in speeding up repigmentation: I have no way of telling if progress would have been slower with UVB treatment alone
- Taking vitamins and psoralen-containing herbs DOES seem to support repigmentation: I have noticed improvement around the eyes where I do NOT use UVB light or piperine for obvious reasons
- Using mineral salts MAY be useful – I have had encouraging signs using mineral-rich skin treatments such as dead sea mud and other salts as a ‘pseudo-catalase’ (look this term up on Google for further explanation).
I hope this information is useful. I will provide another update in the near future.
Hi Jason can we please get an update thanks
HI Jason eagerly awaiting for your updates
HI
I JUST JOINED THIS LIST AND I AM EXPERIMENTING MYSELF WITH THE PIPERINE. JUST STARTED ! CAN’T WAIT TO SEE IF IT WORKS. I BOUGHT THE OIL AND APPLY DIRECTLY TO VIT AREA. DOES NOT BURN, STING NOR ITCH.
CARO
Hi – a few people have asked for an update. I posted an update a while ago but it is still with an ‘awaiting moderation’ status. I assume this might be published once it has been checked for the rules of this forum. Jason.
Hi all,
And now for something completely different! Some scientists in India have found that the humble chickpea may be beneficial for vitiligo treatment: see links:
http://mangalorean.com/news.php?newstype=local&newsid=110338
http://www.nutritiondata.com/facts/legumes-and-legume-products/4326/2
Jason.
hi, I dont know why the site moderator has not included Jasons response here, i think there is something negetive that has been with Jasons experience with peperine and the Moderator doesnt want to include the failure of peperine in this website.
Jason try some other way to convey your message to us…. we are waiting
Hey Jason,
it they do not allow your detailed response, please just tell your experience in 2 words…
Your experience with peperine was -
1 A Miracle
2 very satisfactory
3 fairly satisfactory
4 poor
5 very poor
Please select any one grade out of these,,,,, Please do it asap, as it is very imp for all of us to know your exp with peperine.
Hi Everyone,
There is no problem with Jason’s responses. We must’ve gotten our email crossed, because I have just been waiting to hear from him for permission to publish his comments as a post, so more people can read it. Jason said yes! and it’s going to be posted today
Thanks for reading!!
I’ve been tryin a homemade pepper and vaseline combination (boiled whole black peppercorns for 10mins…drained then vigerously mixed into some aloevera vaseline) on my left elbow so I can compare it to my right one since the 11th feb…. im going to keep applying 2wice daily to see what results i get…as yet i feel like its darkening but obvously its too early to tell. I’ll keep this thread posted and hopefully have some successful photographs to show people if anyone interested
sod the peppercorns – im going to change that ingredient with bioperine asap as it has 95 percent piperine content. keeping the vaseline unless anyone KNOWS another substance would be better to take the piperine to the correct skin layer. anyone?
Hi all,
I still don’t see the post.
For those who want a quick answer, I’d say that piperine MAY have been beneficial, but it’s hard to tell because I have also been using NB UVB – i.e. there is no way of telling what result I would have got with UVB alone. However, I do have definite results that are satisfactory – i.e. while it is NOT a ‘miracle cure,’ and progress is slow, there is no doubt that some areas have 100% repigmentation and that there is roughly 50% improvement overall. I still have a way to go before I’d call this a ‘cure,’ but I am going to continue for another few months at least. BTW, there have been no APPARENT side effects that I can detect.
Anyone else got anything to report?
Please read the full post when it appears.
Jason.
hi jason,
your comments (which includes the wording u sent via email) can be found on the front page of vitiligocover.com in the headline section at the top of the page.
thanks for all of your diligent record keeping…it’s going to help a lot of people
all the best
nathalie
hi just thought i’d let everyone know i have been using the black pepper oil for about three weeks. i also have sat in the sun for a few minutes a couple of days,not to easy since it is still kind of cool weather here. i have noticed some tiny brown spots very light and hard to distinguish i am hoping it is not just wishful thinking.i think i may try the oleoresin since there was no info as to how much pipperine is in the oil.will let you know how things are going.
two questions can i get selsum blue shampoo without prescription??
and how can i get piperine and where??
how can i get this website email me at amiguero1999@hot please
anyone ever use vitiligo tab and any luck
Hi all.
As some of you know, I’ve been using myself as a ‘guinea pig’ for a while using different products/treatments. So far so good. I am responding to a couple of recent posts.
1. Piperine is easily available via Internet – just search on ‘piperine’ or ‘bioperine.’
2. Selsun Shampoo is used to cure some fungal infections which can make skin whitish in colour, but is not effective (as far as I know) for vitiligo. It does contain selenium, but I doubt that’d be very effective alone.
3. Vitiligo Tab increases the photosensitivity of the skin and turns it a golden brown colour – i.e. all over the body, not just in the vitiligo patches unfortunately (in my experience) – but I think it may be useful in combination with sunlight or NB UVB.
I am going to write up another ‘report’ on my progress soon – lately my vitiligo has improved quite quickly, and I think it is because I have altered what I am doing slightly.
Currently, I use a combination of approaches: supplements (antioxidants + herbs/vitamins) topical treatments (occasional use of piperine and daily application of a mineral salt scrub to approximate the ‘pseudocatalase’ effect – search on this term for more info) + NB UVB light treatment. I need to include and exclude each of these to work out what elements(s) is/are most effective.
Once I work this out, I’ll report back.
Anyone else having long-term improvement?
Jason.
Hi Jason
you said vitiligo tab turns body golden brown, is this pigment or food colouring like beta careteen
does vitiligo tab hide it in summer time
Rich,
The pigmentation (in my case) is generalised, so it tends not to mask the contrast between white patches and the rest of the skin – then again, I think it does help, especially if used with low does of NB UVB or sunlight. Be careful tho – these tablets contain herbs that make the skin more photosensitive, so you risk sunburn if you stay in the sun too long. Jason.
Rich – ps, i am referring to the effect of vitiligo tab only – the NB UVB reduces the contrast beteen white and dark skin because you only expose the white areas, so only these areas darken. J
thanks for info
last week started nb therapy, this week started applyiny 30mg peperine with small container of base cream on left hand and on right 5mg of peperine mixed with saliva the way natives did, will post results if I see anything, applying every second day, will up to everyday next week
no burning or tinkling with saliva or base cream
hi everybody…recently found this site..i hv vitilgo since the past 20 years and have tried almost every bit…..have a small spot on my back… NB-UVB does show good results… got back 50% pigment in my case… but recntly i noticed few spots on my left arm..it is very depresing to see them…and worst of all to deal with the fear of spreading…it taking my life away…im loosing my charm of life….gtn all the more depresive by evey passing day…. going to start with black pepper treatment now…hope so it is of some help…
hi sharon,
try not to feel depressed. we are all here for you! why don’t you join our support group? it’s a wonderful community of people with vitiligo- you can communicate via email and we recently added a chat area.
i send you a hug
nathalie
Hi Jason,
Really interesting to hear your results, I’m booked in to go to germany to go on the psuedocat. trials but keen to get started now on some sort of regimine as there’s no time to waste. My vit has become grossly disfiguring and is rapidly taking over my entire body.
I’ll be doing the b12, folic acid & vit c supplementation along with either a) uvb exposure at a local clinic or b) natural exposure daily in an area I’ve prepared at home. I’ll also be massively increasing my natural intake of catalase through eating lots and lots of fresh fruits and vegetables and will of course be avoiding tumeric as we all know this was shown to inhibit repigmentation in the german trials.
Given your comments and the concerns about comfort and effectiveness of piperine I will not be approaching that for a while. Particularly as I’ve not had children yet so want to ensure my body is healthy for that (something men don’t have to worry about as much!)
Questions:
Do you have a blog or website that you can share showing pictures or outlining your experience in detail?
Have you experiemented with natural vs uvb light exposure? Which is preferred?
I have started a blog but it would be great to see yours. I will share mine if and when I start to see results.
You mentioned something about a mineral salt scrub to simulate the psuedocatalase effect… may we have some more information on this? I’ve not heard of another alternative to achieve this effect but am very keen for cost and health reasons to know of one. I’d love to hear if this has altered your repigmentation experience compared to your former regime.
Kind regards and thanks for sharing regularly and reliably. It’s appreciated.
tanx nathalie….
Sharon, it is my great pleasure!
All the very best to you,
Nathalie
ps. one more thing. Vitiligo is sometimes a pre-diabetic condition. Since I have 9 people in my family with diabetes I’ll also be going sugar free over that time. Is anyone interested in tracking my progress? Miss Nathalie, what are the rules of this board, can I post a blog address here? Cheers, Jessie
jessie
found this online
Leucoderma treatment using Turmeric
Turmeric mixed with mustard oil has also proved useful in leucoderma. About 500 gm of turmeric should be pounded and soaked in 8 litres of water at night. It should be boiled in the morning till only one litre of water is left, and then be strained and mixed with 500 ml of mustard oil. This mixture should be heated till only the oil is left. It should then be strained and preserved in a bottle. The mixture should be applied on the white patches every morning and evening for a few months
Turmeric & mustard oil
Turmeric has great importance in Indian system of medicine where it is used as anti-septic and an anti-inflammatory substance. It is a very fine immune booster and also used on wounds to prevent them from bacterial infection. Mustard oil is also a very beneficial for home treatment of many diseases. Its daily body massage provides strength to the immune system. It is an anti-bacterial oil and is also used for detoxification.
How to use:
Take 5 teaspoons of turmeric powder and mix in 250 ml of mustard oil and apply on the white patches of skin, twice a day. Use this treatment regularly for one year. It will have a very useful effect on your Vitiligo. You will observe a very good result of this treatment in your skin. The white sports will start diminishing and will ultimately disappear. It is a very safe remedy
Hi Rich,
That’s interesting,
Where did that come from? Is it ayurvedic? There’s a lot of stuff out there that isn’t proven. Some vedic stuff doesn’t work well either in my experience. Professor Schallreuter’s research indicates tumeric inhibits repigmentation and must not be eaten while under treatment. She discovered this because many of her Indian patients weren’t responding to treatment, they managed to identify the turmeric as the culprit.
In saying that she is talking about eating turmeric as opposed to applying it to the skin. Also from what I understand Turmeric shares an ingredient with Black Pepper, so, maybe it’s true? There is a big difference between applying something to the skin and eating it.
Have you heard of or do you know of anyone who’s spots disappeared this way? Perhaps you might find someone who can vouch for it’s effectiveness? A blog? You perhaps? About 30% of my body has been ravaged by this disease so I’m interested in seeing photos of treatment from real people.
One of the struggles is wading through the scam websites out there. It’s great to be talking to real people for once! I’ll be blogging my results, anyone else got a blog they’d like to share?
:0) Thanks Rich
I began to see white spots on my chin, one on each side, there was also a spot on my wrist bone. The hair on my chin was also white. My doctor prescribed protopic. The spots are gone. I urge everyone to speak to your doctor about protopic. I use it twice a day.
dallasguy did hair turn back to colour
I have vitiligo for 30years now 35 sucks when body hair starts turning white
Jessie found info on net after i was trying to find out what tumeric was
I might give it a try after nb is done end of june
Well the research definitely implies that high doses of folic acid (5mg 2x per day) and 1000mcg of B12 per month (either by injection or daily drops under the tongue of 50mg) are fundamentals so make sure you do that.
Those quantities came from my dermatologist, any questions I’d check with your own or at least a doctor. Pharmacist can provide over the counter high potency folic acid in my country, probably yours.
on right hand have 4 new dots all quarter inch apart size of *
starting today going to apply peperine morning and night. I go to nb tratment 2 days aweek
will update if more results
hi rich,
thanks for the update. it’s so exciting to see new freckling, isn’t it?
these spots don,t show up using wood light, they almost look like the little bumps on caps the paper strips you rub a rock and make a spark when you were kids, they only have a faint color.
will keep close eye on them
DO I BUY PIPERINE POWDERAND MIX IT WITH A CREAM OR OIL PIPERINE? AND HOW LONG DO I LEAVE THE PIPERINE BEFORE ADDING UV? “SUNLIGHT”.
crush pills to make powder unless you can get powder form
some are using cream base or lotion from pharmacy
the peperine absorbs in skin i dont take off
if you go back in post it shows how much and what they mixed with, check outjason
Someone give me the cure for vitilgo im young and still been trying to find the cure oh ive been living with this condition starting at 6 and now im 12 the black pepper idea didnt work so i want this website to give me an idea of a cuban pill in cuba if it will work and it is 600$ if andone used it please respond
istri saya menderita vitiligo dan tergolong universalis,artinya sudah hampir merata lebih dari 50% seluruh tubuh, kami mungkin akan mencoba memutihkan daerah yang gelap dari pada menumbuhkan melanosit daerah yang terkena vitiligo,karena telah bertahun-tahun telah kami lakukan dan hasilnya kurang memuaskan dengan psoralen.saya ingin tanya apakah dengan produk-produk kosmetik pemutih yang aman apakah hal itu bisa bekerja dengan baik?dan apakah ada yang tahu tentang mobenzil hidrokuinon??tks. God Bless u all
Hi,
I have A-levels in biology and chemistry so I have a semi-decent understanding of the subjects. So can someone please explain SCIENTIFICALLY how this active ingredient in black pepper actually stimulates the production and activity of melanocytes? Im told that is what it does but nobody explains why.
If anyone can help I would be most grateful.
Thanks
Rich I noticed you had repigmentation showing on your ‘right’ hand…the one you are using less piperine as opposed to the other???
Rich says: “last week started nb therapy, this week started applyiny 30mg peperine with small container of base cream on left hand and on right 5mg of peperine mixed with saliva the way natives did, will post results if I see anything, applying every second day, will up to everyday next week
no burning or tinkling with saliva or base cream”
the left hand has less its a small container with 30mg mixed with base, i dab finger in I dont use whole container just dab on finger
peperine is used in most bodybuiding products to make your body absorb supplement better
just got black pepper oil in mail
going to mix black pepper oil and melatonin 5mg together on left and on right peperine 10mg with melatonin 10mg on right
melatonin is hormone to make melenin
for nb I,m up to 1min and 10secs
Hi all,
Since I started researching vitiligo, i.e. soon after I first got vitiligo about 18 months ago, I have always searched for new developments by limiting my Web search results to new content – i.e. within the last month.
I recently found information that a very promising topical treatment had been discovered in Venezuela by some researchers who have named the treatment ‘Vitilvenz.’ Most info about this is currently in Spanish, but the patent is published in English. The ingredients are:
Extract of Pimienta racemosa
Extract of Citrus aurantifolia
Coenzyme Q-10
Pyridoxine Chlorhydrate
Extract of Cucumis melo
Out of curiosity, I looked these up and found I could easily purchase the first four of these ingredients, the first two of which are available in the form of an essential oil.
I have applied this mixture (in a carrier oil – avocado) to vitiligo areas that have resisted treatments that I have tried and discussed in my former posts – i.e. NB UVB + some other topical treatments, including piperine.
I have been doing this for only a week, and I have to say that the early indications are extremely good. I have noted signs of improvement in the most obstinate remaining areas of vitiligo very quickly – everything else I have been doing has been painfully slow!
I have used myself as a bit of guinea pig ever since I got vitiligo, and to be honest, this seems to be the most promising treatment I have tried – to the extent that I have actually stopped everything else, including NB UVB and piperine, in favour of this.
I will certainly update this forum as I continue to try this topical treatment that seems amazingly simple and promising.
Jason.
PS
By the way, I’d be interested to hear from the people in this forum if they tend to suffer from irritation of the lower intestinal tract -there seems to be a lot of evidence suggesting that there is a connection between vitiligo and irritable bowel and/or colitis.
Also, how many people also suffered some form of stress or trauma in the period before they noticed vitiligo?
I have become really interested in vitiligo now, and want to compare my own experience with others.’
Please let me know!
Jason.
Thanks Jason for your research and subsequently findings..
Where were you able to find the ingredients..at a local health food store?
And I certainly had some form of IBS before I contracted vitiligo..
Thanks..and all the best.
Again did some research, especially on Vitiligo Support, and found out that this product has been in existence since 2005 and not many supporters out there..
hi jason,
nice to hear about your improvement…can u tell me more about how u r using all this stuff..about all the ingredients..wether u took powder or liquid form and how did u mix??..i too want to try…hope it turns out to be my dream come true…n yes my vitilgo does get aggravated under stress…it has a very slow progression otherwise but recently due to stress it seems to come out rapidly…
at present im trying with peprine n chickpea combination since 2 weeks..but no improvement…
hope to hear soon from u..
has anybody else also tried this with any positive results??
Yes I have IBS also. Surprised you saw results so quickly, please post the exact recipe once you have confirmed your results. Also, so many people say they have results but very few have photos, don’t suppose you have a blog or any images you can share?
hi Jason
you sure its not the avocado
avocado has alot of tyrosine and most likely tyrosinase
hes ifo onit
The aim of this patent is the elaboration of a natural product based on vegetal ingredients with anti-vitiligo therapeutic properties to be employed in the white patches of depigmentation present in the skin with vitiligo and to achieve melanocyte regeneration, which is dysfunctional during the disease. At present, there are evidences indicating a pathogenic association between vitiligo and the increase in epidermal oxidative stress, mechanism underlying the functional alterations in the melanocytes and vitiligo development. It is for this reason that this treatment that we present in this patent application emerges as a natural product with anti-vitiligo therapeutic properties, which contains as active ingredients the watery extract of Pimienta racemosa; this active ingredient inhibits neutrophil chemotaxis and superoxide anion production and acts in this way like an antioxidant on the skin with vitiligo, promoting the restoration of the affected area. Moreover, it contains watery extract of melon, which supplies antioxidant enzymes like catalase and superoxide dismutase, these antioxidant enzymes are free radicals scavengers present in melanocytes. Coenzyme Q-10 is other active ingredient, it helps these enzymes to develop their function besides having antioxidant properties, and it plays an important role in the production of cell energy, and therefore it is an important mitochondrial and immunological stimulator. It also contains Pyridoxine, which is necessary for the metabolism of amino acids like tyrosine and phenylalanine which participate in melanin production and the lemon terpene which contains vitamin C or ascorbic acid which also acts as an antioxidant inhibiting free radicals developing. Its formula is given by: 1:1 of watery extract of Pimienta racemosa; 1:2 of watery extract of Cucumis melo; 100 ml of extract of Citrus aurantifolia; 100 mg Coenzyme Q-10 and 100 mg Pyridoxine Chlorhydrate
Hello,
Jason thanx for your info…Im going to try this ‘pseudocatalase cream’ as follows please let me know if you think this is similar to your mixture…
1:1 of watery extract of Pimienta racemosa; Plant extract (essential oil)
1:2 of watery extract of Cucumis melo; Kalahari Melon oil (essential oil)
100 ml of extract of Citrus aurantifolia; Key Lime extract (essential oil)
100 mg Coenzyme Q-10; (100mg capsules available)
100 mg Pyridoxine Chlorohydrate; IS THIS VITAMIN B6??? (Vitimin B6 100mg capsules available)
All in a carrier oil – EMU OIL.
Apparently this ‘VITILVENZ’ cream (http://www.vitilvenz.com) is free in other countries as its part of a Government test??? Im trying to find out if I can get any….
My current regime of piperine in Emu oil (applied twice daily) will continue as im having promising results on my left elbow with a few small repigment spots after 4 weeks. Im not treating my right elbow so I can compare the two and Im not using Narrowband UVB on these areas yet.
Is Pyridoxine Chlorohydrate vitimin B6???
where do u get coenzyme Q 10 n pyrisoxine chlorahydrate nwith what names?? ny cure for spreading vitilgo??
coenzyme Q 10 is available at health food store the other is b6
other name: ADERMINE HYDROCHLORIDE
autre dénomination : CHLORHYDRATE DE PYRIDOXINE other name: PYRIDOXINE
autre dénomination : PYRIDOXINIUM CHLORURE other name: PYRIDOXINIUM CHLORIDE
autre dénomination : PYRIDOXOL CHLORHYDRATE other name: PYRIDOXOL HYDROCHLORIDE
autre dénomination : RP 2980 other name: RP 2980
autre dénomination : VITAMINE B 6 alternative name: Vitamin B 6
autre dénomination : VITAMINE B6 other name: VITAMIN B6
I had to respond to the IBS question. I’m 32 now; I was diagnosed with vitiligo just two years ago, at 30.
However, I was diagnosed with IBS at 18… it’s been a long time, but under some control now.
By the way, I’ve stabilized my vit with Ginko Biloba — research has shown it’s effectiveness. I started taking it last September, in addition to my other supplements — B12, Folic Acid, CoQ10, Fish Oil and a multi. My vit isn’t spreading rapidly like it was in the beginning. In fact, I don’t think it’s spreading at all anymore.
… in saying that… mine can be quiet for ages, with no apparent reason, then all of a sudden a rapid period of depigmentation. It can be stable for years.. then boom! More patches.
HOW LONG DO I KEEP THIS PIPERINE AND VEGETABLE OIL ON MY SKIN FOR BEFORE DOING THE UVB?
any updates from jason??? regarding the new treatment..
Hi everyone – I am only going to update the ‘Jason’s Experiment’ forum/thread from now on, as I don’t want to cross-post. This is accessible from the vitiligocover.com website.
Good news is that the ‘Vitilvenz’ compound (see above posts about various plant extracts) is working really well on the remaining areas of Vitiligo that I have. This is, in my opinion, the most hopeful treatment I have trialled. The areas of my skin that are freckled are becoming very evenly pigmented, and relatively quickly too.
I’d recommend it – but be careful not to use too strong a mixture – it can make the skin a bit irritated.
I’ll keep you posted from the “Jason’s Experiment” thread/forum.
Jason.
Incredible site!
[...] Black Pepper May Help Vitiligo | Vitiligo [...]
2 question from my side..
1. any updates regarding the trial going in oregan with black pepper…
2. anyone has tried antivitilgo oil frm net??? any results??
Jason are you making your own “vitilvenz” ? or you are ordering from Venezuela ?
How are you making it ???
caro
On the issue of stress, I think it has a huge impact on getting vitiligo. I believe it causes mine. I am going to try some anti-anxiety medication and I will let you all know if it works. I can’t seem to de-stress myself naturally no matter how hard I try!
hwz peprine applied to skin??? before the ub / sunlight or after the ub/ sunlight
Hi everyone .
Very interesting site to get ideas from others. I’ve been following Jason’s trials with special interest, since it seems he’s been googling as much as I have.
My Vit started about 10 yeas ago (I’m 51) with a small patch on my neck, then little by little as years went by, other spots in fingers, feet, around mouth, forehead, etc. Elidel seem to work for a while on my face, but then after some years became ineffective. Tried everything else available like Clobetazol (steroids), tacrolimus, khelina, melagenina, etc., with no results.
For the past 4 weeks I’ve been using piperine : bioperine tablets grinded and mixed with a aftershave balm, so that the mixture drieds quickly on my skin and I’m able to continue with normal life. I also take supplents : silimarin (helps liver), VIT B12, Coenzyma Q- 10, VIT E and Ginkgo Biloba. I’m very satisfied with results on face now almost 100% normal. On neck, legs and under arms i see some freckels and size of lesions have shrank. I don’t see results on my fingers yet, but color seems not as white as before.
I will post in another month for an update.
God bless you.
Hi I’m a student of M.Pharmacy in india.Iwant to know how much %of piperine is safe to use for topcal preparatons.If u provide this information,’l b thankful to u.
Hello everyone,
I have vt on my face and am in need of a good cover up makeup for black skin. My problem is that the makeup gets oily after a few hours.
Suggestions on a good brand?
A Dr. Benjamin Sieve injected PABA with monoethanolamine and allegedly had 100% success. After considerable research, I have been unable to find Dr. Sieve’s clinical text on the process? Please post a link to the process if discovered…
i am from the philippines and its like 2 years ago when i noticed a white spot on my ‘male organ’ part and then its getting bigger and bigger as times go by..right now my shaft is almost white. i just know its vitiligo when i searched it here in the net, i alos have a little spot on my butt..and then small white patches on my back wrists and then some on my knee. i am very desperate to cure this so i started taking vitamin c, gingko biloba, and i drink carrot shake once a day and then i eat lots of spinach..its too early for me to tell right now..i woudl like to know if how many times do i have to take the B12? can i take it once a day or what? how bout the folic acid? its good to know that i am not alone in this battle..cheers!
Hey everyone, I have had vitiligo for over 10 years and recently went India to find a cure for it. The doctors that I went to see are very professional and have the cure for vitiligo. They told me that I can not eat any meat, chicken or fish and avoid dairy products i.e. become vegan. I have done this for a month so far and it has been working really well.. I had very big patches on my eyes before I tried this and a month later, most of it has disappeared. Maybe you should try changing your diets too?
Hope this helps
x
To A
Who were the doctors that you saw in India? Besides going vegan
did you take any other medication or remedies?
[...] Black Pepper May Help Vitiligo | Vitiligo [...]
Hello A. I wanted to know if there was any other medication the doctor gave you, besides the new diet you have? A. Can you tell me how much improvement have you seen since you started? I am from the U.S. and I have had it for 35 years and I am searching for cure. Please let all of us know so we can pursue the cure.
Thank you
M
hi everybody….my vitilgo is spreading : (…my skin gets a bit itchy….dry n flaky and then bloches develop….im sick of it now…. any way..any damn way that it could stop if not cured…